METHOD FOR PREDICTING OUTCOME OF INFECTIOUS PROCESS AFTER A NEW CORONAVIRUS INFECTION FOR 12 MONTHS Russian patent published in 2023 - IPC A61B5/205 G01N33/68 G01N33/84 

FIELD: infectology.

SUBSTANCE: used to predict the outcome of the infectious process within 12 months after a new coronavirus infection. A study of biochemical blood parameters is carried out together with clinical parameters. The content of TNF-alpha, nitrites, MDA, the activity of trypsin-like proteinases, and the activity of elastase-like proteinases are determined in the blood serum. Discriminant functions Y1 and Y2 are calculated using the equations:

Y1 = -249.778+0.049x₁+4.650x₂+5.145x₃+0.202x₄-0.022x₅-34.823x₆+19.838x₇+5.990x₈-16.499x₉+24.184x₁₀ – unfavorable outcome,

Y2=-112.293+0.007x₁+3.241x₂+3.518x₃+0.133x₄-0.016x₅-22.405x₆+17.880x₇+3.379x₈-6.450x₉+14.531x₁₀ – favorable outcome, where

Y is the linear discriminant function;

x₁ is the TNF-alpha content, pg/ml;

x₂ is the nitrite content, µmol/l;

x₃ is the MDA content, µmol/ml;

x₄ is the activity of trypsin-like proteinases, nmol BANE/min⋅ml;

x₅ is the activity of elastase-like proteinases, nmol BANE/min⋅ml;

x₆ is the presence of malignant neoplasms: 1 is the absence of malignant neoplasm; 2 is the presence of malignant neoplasms;

x₇ is the presence of hypertension; 1 is the absence of hypertension; 2 is the presence of hypertension;

x₈ is the presence of type 2 diabetes mellitus: 1 is the absence of type 2 diabetes mellitus; 2 is the presence of type 2 diabetes mellitus;

x₉ is the presence of gastrointestinal diseases: 1 is the absence of gastrointestinal diseases, 2 is the presence of gastrointestinal diseases;

x₁₀ is the presence of respiratory failure during the period of infection with a new coronavirus infection: 1 is the absence of respiratory failure, 2 is the presence of respiratory failure. If Y1>Y2, an unfavorable outcome of the infectious process is predicted after suffering a new coronavirus infection for 12 months. If Y1<Y2, then the favorable outcome.

EFFECT: increasing the information content of predicting the outcome of the infectious process within 12 months after suffering a new coronavirus infection by studying biochemical blood parameters together with clinical parameters and conducting analysis using a mathematical apparatus.

1 cl, 2 tbl, 2 ex