FIELD: chemistry.
SUBSTANCE: present invention relates to technology of drugs, to synthesis of a drug for Alzheimer's disease, specifically to a method of producing 2-hydroxy-5-[2-(4-(trifluoromethylphenyl)ethylamino)]benzoic acid. Method includes such steps as introduction of protection of compound I to obtain compound II, further condensation of compound II with methyl-5-aminosalicylate to obtain compound III and its subsequent hydrolysis to obtain desired compound IV, where R is any of n-methylbenzene sulphonyl, n-nitrobenzene sulphonyl, benzenesulphonyl, trifluoromethanesulphonyl and acetyl.
EFFECT: high quality and yield of the end product.
13 cl, 5 dwg, 5 ex
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