FIELD: chemistry.
SUBSTANCE: invention relates to a method for synthesis of (3aR,4S,8S,12R,12aS,12bR)-10-methyl-2-phenyl octahydro-1H-4,12a-etheno-8,12-methanopyrrolo[3',4':3,4]pyrido[1,2-a][1,5]diazocine-1,3,5(4H)-trione of formula 1, involving reaction of methylcytisine with N-phenyl maleimide in organic solvents at high temperature. Reaction is carried out in an autoclave, followed by crystallisation of the end product from ethyl acetate.
EFFECT: obtaining a compound of formula 1 with high output without using excess N-phenyl maleimide, high static pressure and column chromatography at the step of isolating the reaction product.
1 cl, 3 dwg, 8 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| QUINAZOLINE DERIVATIVES, POSSESSING NOOTROPIC AND ANTIHYPOXIC ACTIVITY | 2012 |
|
RU2507198C1 |
| DRUG POSSESSING ANTIHYPOXIC, ACTOPROTECTIVE, NOOTROPIC ACTIVITIES AND HAVING EFFECT ON PHYSICAL EFFICIENCY, AND BASED PHARMACEUTICAL COMPOSITION | 2011 |
|
RU2462245C1 |
| METHOD OF PRODUCING AGENT HAVING NOOTROPIC AND ANTIOXIDANT ACTIVITY | 2024 |
|
RU2839867C1 |
| MEDICINE COMPOSITION, POSSESSING NOOTROPIC ACTIVITY | 2007 |
|
RU2331432C1 |
| 2-HYDROXY-4-METHYLPHENYL-4-OXO-2-BUTENOATE OF THIAZONYL AMMONIUM, POSSESSING HYPOGLYCEMIC AND NOOTROPIC ACTIVITY | 2011 |
|
RU2512291C2 |
| 2-(4-CARBONYLBENZYLIDENE)DIPTEROCARPOL EXHIBITING HYPOGLYCEMIC ACTIVITY, USE THEREOF AND METHOD FOR PREPARATION THEREOF | 2024 |
|
RU2841339C1 |
| PEPTIDE FOR TREATMENT OF ALZHEIMER'S DISEASE | 2017 |
|
RU2678987C2 |
| N-(5-HYDROXYNICOTINOYL)-L-GLUTAMIC ACID MONO- AND BIVALENT SALTS POSSESSING PSYCHOTROPIC (ANTIDEPRESSANT AND ANXIOLYTIC), NEUROPROTECTIVE, GEROPROTECTIVE AND ANTI-INSULT EFFECT | 2006 |
|
RU2314293C1 |
| MEDICATION, PROVIDING NEURO-PROTECTIVE ACTION IN ACUTE PERIOD OF CRANIOCEREBRAL INJURY | 2009 |
|
RU2414901C2 |
| ANTIDEPRESSANT AGENT | 2018 |
|
RU2741938C2 |
