METHOD FOR CORRECTION OF SPASTIC MICROCIRCULATORY DISORDERS IN POLYNEUROPATHY OF LOWER EXTREMITIES Russian patent published in 2025 - IPC A61H1/00 A61B5/296 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to occupational pathology, neurology, endocrinology, can be used for treating polyneuropathies with vascular disorders, for example, in vibration disease, in Raynaud's syndrome, in diabetes mellitus. In the sitting position, the ischemia-reperfusion episodes are performed by cyclic injecting air up to 210 mm Hg into the mechanical tonometer chamber put on the patient’s shoulder, controlling the exposure time with a stopwatch. One day before the beginning of treatment and on 30th day of the course of treatment, the patient undergoes examinations: laser Doppler flowmetry (LDF) and electroneuromyography (ENMG) of lower extremities; one-month ischemic preconditioning sessions are performed intermittently; the exposure regimen is as follows: 1 day, right hand – 2 min of ischemia, 2 min of reperfusion, 3 min of ischemia, 3 min of reperfusion, 4 min of ischemia, reperfusion; 2-3 days – break; 4th day, left hand – 2 min of ischemia, 2 min of reperfusion, 3 min of ischemia, 3 min of reperfusion, 4 min of ischemia, reperfusion; 5-6 days – break; 7th day, right hand – 3 min of ischemia, 3 min of reperfusion, 4 min of ischemia, 4 min of reperfusion, 5 min of ischemia, reperfusion; 8-9 days – break; 10th day, left arm – 3 min of ischemia, 3 min of reperfusion, 4 min of ischemia, 4 min of reperfusion, 5 min of ischemia, reperfusion; 11-12 days – break; 13th day, right arm – 3 min of ischemia, 3 min of reperfusion, 4 min of ischemia, 4 min of reperfusion, 5 min of ischemia, reperfusion; 14-15 days – break; 16th day, left arm – 3 min of ischemia, 3 min of reperfusion, 4 min of ischemia, 4 min of reperfusion, 5 min of ischemia, reperfusion; 17-18 days – break; 19 day, right hand – 4 min of ischemia, 4 min of reperfusion, 5 min of ischemia, 5 min of reperfusion, 5 min of ischemia, reperfusion; 20-21 days – break; 22 day, left arm – 4 min of ischemia, 4 min of reperfusion, 5 min of ischemia, 5 min of reperfusion, 5 min of ischemia, reperfusion; 23-24 days – break; 25th day, right hand – 5 min of ischemia, 5 min of reperfusion, 5 min of ischemia, 5 min of reperfusion, 5 min of ischemia, reperfusion; 26-27 days – break; 28th day, left arm – 5 min of ischemia, 5 min of reperfusion, 5 min of ischemia, 5 min of reperfusion, 5 min of ischemia, reperfusion; 29th day – break; 30th day – repeated control examinations: ENMG and LDF.

EFFECT: due to distant effects of ischemic preconditioning method provides reduction of spastic phenomena in microvasculature of lower extremities, increased speed of somatic sensory nerves of lower extremities, as well as gradual adaptation and increased tolerance of somatic sensory nerves of lower extremities to hypoxia as a pathogenesis factor of polyneuropathy.

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