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IPC

A61K31/75(2006-01-01)

A61P15/06(2006-01-01)

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Application

2011136310/15, 2011-08-31

(24)

Start date

2011-08-31

(22)

Actual filing date

2011-08-31

(45)

Published

2013-05-10

(72)

Inventor

Pokrovskij Mikhail VladimirovichGureev Vladimir VladimirovichPoljanskaja Oksana SergeevnaArtjushkova Elena BorisovnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichBelous Aleksandr SergeevichTsybul'Skij Igor' Valer'EvichKotel'Nikova Lilija ViktorovnaDenisjuk Tat'Jana AlekseevnaTerekhova Elena Gennad'EvnaBabko Anna VladimirovnaAlekhin Sergej AleksandrovichAlekhina Valerija Valer'EvnaMostovoj Aleksandr SergeevichLebedev Kirill AleksandrovichStarosel'Tseva Ol'Ga AleksandrovnaZhukov Sergej VladimirovichKaplin Anton Nikolaevich

(73)

Holder

Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii

METHOD FOR PLACENTAL MICROCIRCULATION DISORDER CORRECTION IN ADMA-LIKE GESTOSIS MODELS IN EXPERIMENT BY SINGLE ISCHEMIC EPISODE Russian patent published in 2013 - IPC A61K31/75 A61P15/06

Abstract RU 2481103 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, namely to experimental pharmacology and may be used for the placental microcirculation correction in pregnant women. Substance of the method involves simulating gestosis in Wistar rats by the daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg for 14th to 20th day of pregnancy. For the purpose of the placental microcirculation correction, what is used is a single 10-minute hind-limb ischemia by clamping the femoral artery in the upper one-third followed by reperfusion on the 21 days of pregnancy, 90 minutes prior to the microcirculation recording.

EFFECT: use of the declared method allows correcting the placental microcirculation disorders during the simulated pathology.

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RU 2 481 103 C1

Authors

Pokrovskij Mikhail Vladimirovich

Gureev Vladimir Vladimirovich

Poljanskaja Oksana Sergeevna

Artjushkova Elena Borisovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Belous Aleksandr Sergeevich

Tsybul'Skij Igor' Valer'Evich

Kotel'Nikova Lilija Viktorovna

Denisjuk Tat'Jana Alekseevna

Terekhova Elena Gennad'Evna

Babko Anna Vladimirovna

Alekhin Sergej Aleksandrovich

Alekhina Valerija Valer'Evna

Mostovoj Aleksandr Sergeevich

Lebedev Kirill Aleksandrovich

Starosel'Tseva Ol'Ga Aleksandrovna

Zhukov Sergej Vladimirovich

Kaplin Anton Nikolaevich

Dates

2013-05-10—Published

2011-08-31—Filed