METHOD FOR PREDICTION OF RISK OF LUMINAL BREAST CANCER PROGRESSION Russian patent published in 2025 - IPC G01N33/574 C07K16/30 

Abstract RU 2836845 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology, and can be used to predict the risk of progression of luminal breast cancer with diameter of not more than 3 cm. Immunohistochemical analysis of histological preparations prepared from patient’s tumour samples is carried out to determine the number of T-lymphocytes CD8+, number of T-lymphocytes CD4+ and number of M2 macrophages CD163. In cells of the invasive edge of the primary tumour, expression of CD4+, CD8+ and CD163 is determined. If the expression of CD163 is less than 20%, and the sum of the expression of CD4 and CD8 is less than 15%, a low risk of progression is predicted. If CD163 is more than or equal to 20%, and the sum of CD4 and CD8 expression is less than 15%, an average risk of progression is predicted. If CD163 is more than or equal to 20%, and the sum of CD4 and CD8 expression is more than or equal to 15%, a high risk of progression is predicted.

EFFECT: method provides higher prediction accuracy, possibility of predicting a strictly defined molecular subtype of breast cancer at early stages by analysing the indicators of the proposed complex of tumour-associated markers with the assessment of the main subpopulations of infiltrating T-lymphocytes and the level of tumour-infiltrating M2 macrophages.

1 cl, 5 ex

Similar patents RU2836845C1

Title Year Author Number
METHOD OF PREDICTING THE DEVELOPMENT OF METASTASES IN PATIENTS WITH UNRESECTABLE TRIPLE-NEGATIVE BREAST CANCER 2023
  • Molchanov Oleg Evgenevich
  • Maistrenko Dmitrii Nikolaevich
  • Granov Dmitrii Anatolevich
  • Semenov Konstantin Nikolaevich
  • Sharoiko Vladimir Vladimirovich
  • Popova Alena Aleksandrovna
RU2802141C1
METHOD FOR DETERMINING THERAPEUTIC APPROACH IN PATIENTS WITH METASTATIC FORMS AND RECURRENT TRIPLE-NEGATIVE BREAST CANCER 2023
  • Molchanov Oleg Evgenevich
  • Maistrenko Dmitrii Nikolaevich
  • Popova Alena Aleksandrovna
  • Semenov Konstantin Nikolaevich
  • Popova Elena Aleksandrovna
  • Protas Aleksandra Vladimirovna
  • Mikolaichuk Olga Vladislavovna
  • Sharoiko Vladimir Vladimirovich
  • Granov Dmitrii Anatolevich
RU2818730C1
METHOD FOR CHOOSING APPROACH FOR NEOADJUVANT DRUG THERAPY FOR LUMINAL T2N0M0 BREAST CANCER 2024
  • Balkanov Andrej Sergeevich
  • Rozanova Ekaterina Andreevna
  • Mikhajlov Ilya Vladimirovich
RU2840757C1
METHOD FOR PREDICTING THE DURATION OF A RELAPSE-FREE PERIOD IN PATIENTS WITH RESECTABLE THRICE-NEGATIVE BREAST CANCER 2021
  • Molchanov Oleg Evgenevich
  • Maistrenko Dmitrii Nikolaevich
  • Granov Dmitrii Anatolevich
  • Popova Alena Aleksandrovna
  • Semenov Konstantin Nikolaevich
  • Sharoiko Vladimir Vladimirovich
RU2780922C1
METHOD FOR PREDICTING THE OUTCOME OF A DISEASE IN PATIENTS WITH LUMINAL AND THRICE NEGATIVE BREAST CANCER IN PATIENTS WHO DID NOT RECEIVE CHEMOTHERAPY OR HORMONE THERAPY IN THE NEOADJUVANT REGIMEN 2017
  • Shashova Elena Evgenevna
  • Kakurina Gelena Valerevna
  • Doroshenko Artem Vasilevich
  • Tarabanovskaya Natalya Anatolevna
  • Slonimskaya Elena Mikhajlovna
  • Kondakova Irina Viktorovna
RU2648523C1
METHOD FOR ASSESSING THE SENSITIVITY OF A TUMOR TO IMMUNO-ONCOLOGICAL DRUGS 2021
  • Molchanov Oleg Evgenevich
  • Maistrenko Dmitrii Nikolaevich
  • Granov Dmitrii Anatolevich
  • Popova Alena Aleksandrovna
  • Semenov Konstantin Nikolaevich
  • Sharoiko Vladimir Vladimirovich
RU2771760C1
METHOD FOR PREDICTION OF LIFE EXPECTANCY IN PATIENTS WITH METASTATIC TUMORS 2023
  • Molchanov Oleg Evgenevich
  • Maistrenko Dmitrii Nikolaevich
  • Popova Alena Aleksandrovna
  • Semenov Konstantin Nikolaevich
  • Sharoiko Vladimir Vladimirovich
  • Popova Elena Aleksandrovna
  • Protas Aleksandra Vladimirovna
  • Mikolaichuk Olga Vladislavovna
  • Granov Dmitrii Anatolevich
RU2821659C1
METHOD FOR PREDICTING THE COURSE OF A PATHOLOGICAL PROCESS IN LUMINAL NON-HYPEREXPRESSION OF Her2Neu PRIMARY OPERABLE BREAST CANCER IN POSTMENOPAUSAL WOMEN 2018
  • Kit Oleg Ivanovich
  • Shatova Yuliana Sergeevna
  • Ulyanova Elena Petrovna
  • Tokmakov Vasilij Vasilevich
RU2694843C1
METHOD FOR PREDICTION OF RISK OF DEVELOPING DISTANT METASTASES IN PATIENTS WITH OPERABLE FORMS OF BREAST CANCER WITH METASTASES IN REGIONAL LYMPH NODES 2020
  • Shashova Elena Evgenevna
  • Kolegova Elena Sergeevna
  • Kakurina Gelena Valerevna
  • Tarabanovskaya Natalya Anatolevna
  • Slonimskaya Elena Mikhajlovna
  • Kondakova Irina Viktorovna
RU2733697C1
METHOD FOR SELECTION OF LOCOREGIONAL RADIATION THERAPY VOLUME AFTER BREAST CANCER SURGERY 2016
  • Balkanov Andrej Sergeevich
  • Rozanov Ivan Dmitrievich
RU2624367C1

RU 2 836 845 C1

Authors

Balkanov Andrej Sergeevich

Mikhajlov Ilya Vladimirovich

Rozanova Ekaterina Andreevna

Dates

2025-03-24Published

2024-05-31Filed