METHOD FOR ASSESSING THE SENSITIVITY OF A TUMOR TO IMMUNO-ONCOLOGICAL DRUGS Russian patent published in 2022 - IPC G01N33/50 G01N33/574 A61B5/00 

FIELD: medicine.

SUBSTANCE: method for assessing the sensitivity of a tumor to immuno-oncological preparations refers to medicine, more specifically to oncology, and can be used in the treatment of malignant neoplasms. The method consists in the fact that before treatment with immuno-oncological drugs in a patient in the blood (B) and microenvironment (M) of the tumor, the relative content of T-regulatory cells (CD4+CD25+CD127-), activated cytotoxic lymphocytes (CD8+HLADR+), spontaneous production of IL-8 and IL-10, induced production of TNF-α and IFN-γ, then coefficients are calculated from the obtained values:

C1 = TREG-M/TREG-B;

C2 = CTL-B/CTL-M;

C3 = IL-8-M/IL-8-КP;

C4 = IL-10-M/IL-10-КP;

C5 = IFN-γ-B/IFN-γ-M;

C6 = TNF-α-B/TNF-α-M.

If the value of all coefficients is less than or equal to 2, the tumor is regarded as sensitive to immunooncological drugs, and if one and/or more coefficients increase above 2, the tumor is regarded as insensitive.

EFFECT: method makes it possible to predict the sensitivity of a tumor to immuno-oncological drugs due to a clear algorithm of actions, as well as to increase the effectiveness of treatment by choosing the most appropriate therapy option.

1 cl, 4 tbl