FIELD: chemical or physical processes.
SUBSTANCE: invention relates to production of glycosaminoglycan hydrogels. Disclosed hydrogel product contains glycosaminoglycan molecules as a swellable polymer. Glycosaminoglycan is selected from hyaluronic acid, heparosan and chondroitin sulphate. Molecules of glycosaminoglycans are covalently cross-linked, containing a spacer group selected from a group, consisting of di-, tri-, tetra- and oligosaccharides. Cross-linked glycosaminoglycan molecules do not contain synthetic non-carbohydrate structures or cross-linking agents. Method of preparing a hydrogel product comprising cross-linked glycosaminoglycan molecules selected from hyaluronic acid, heparosan and chondroitin sulphate, comprises providing a solution of glycosaminoglycan molecules; activation of carboxyl groups on molecules of glycosaminoglycan using a binding agent to form activated glycosaminoglycan molecules. Thereafter, the activated glycosaminoglycan molecules are cross-linked by their activated carboxyl groups using a di- or multinucleophilic functional cross-linking agent, containing a spacer group selected from a group consisting of di-, tri-, tetra- and oligosaccharides to form cross-linked glycosaminoglycans. Cross-linked glycosaminoglycans do not contain synthetic non-carbohydrate structures or cross-linking agents. Also disclosed is a method for cosmetic skin treatment using said hydrogel product.
EFFECT: invention is aimed at obtaining a hydrogel product from glycosaminoglycan, which is closer in structure to natural molecules than hydrogel products known from the state of the art.
16 cl, 3 tbl, 6 ex
