METHOD FOR ASSESSING RISK OF UNFAVOURABLE OUTCOME FOR PATIENT WITH CIRRHOSIS ON LIVER TRANSPLANTATION WAITING LIST Russian patent published in 2020 - IPC A61B5/00 G01N33/49 G01N33/50 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to hepatology and transplantology. Patient, in addition to the MELD-Na index, takes into account the age, the nature of hepatic impairment, blood leukocyte count, presence of portal vein thrombosis. Each score is assigned with corresponding points: if the patient's age is less than or equal to 43 years, 1 point is scored, while the patient's age from 44 to 51 years old - 2 points, if patient aged 52 to 57 years old - 3 points, if the patient's age is more than or equal to 58 years, 4 points are scored. If the patient suffers chronic hepatic insufficiency, 1 point is scored, if acute hepatic impairment - 2 points. If the MELD-Na index is less than or equal to 17, 1 point is awarded, while the MELD-Na index from 18 to 20 shows 2 points, while the MELD-Na index from 21 to 24 shows 3 points, while the MELD-Na index is more than or equal to 25 - 4 points. If leukocyte level is more than or equal to 3.8×10⁹/l is 1 point, with leukocyte level of 3.2 to 3.7×10⁹/l - 2 points, with leukocyte level from 2.8 to 3.1×10⁹/l - 3 points, with leukocyte level less than or equal to 2.7×10⁹/l - 4 points. If portal vein thrombosis is present, 1 point is scored, if absent - 0 points. Obtained points are substituted into original formula and index value is calculated, which enables to determine probability of death in patient waiting for liver transplantation for one year.

EFFECT: method provides higher accuracy of assessing the risk of unfavourable outcome (death) of a patient for one year, enables solving the question of assessing the effectiveness of treatment and priority distribution of donor organs.

1 cl, 3 dwg, 7 tbl, 5 ex