FIELD: chemistry.
SUBSTANCE: invention relates to a compound of formula (Ic), which is a modulator of transient receptor potential melastatin type 8 (TRPM8) channels, and can be used to achieve cooling effect on skin or mucous membrane. Values R1, n, X1-X3, Z, R4-R6 are given in the claims. Invention also relates to non-medical methods for modulating TRPM8, inducing a sense of cooling and achieving a cooling effect on the skin or mucous membrane, involving contact with a compound of formula (Ic), use thereof to create a cooling sensation and a consumer product and composition containing same.
EFFECT: substituted azacyls as TRPM8 modulators are disclosed.
11 cl, 3 tbl, 197 ex
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