PHARMACEUTICAL COMPOSITION, METHOD FOR PREPARATION AND USE THEREOF Russian patent published in 2025 - IPC A61K31/575 A61K47/10 A61K47/18 A61K47/26 A61K47/38 A61K9/10 A61K9/107 A61P27/02 A61P27/12 

FIELD: chemistry; pharmaceutics.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, specifically to a pharmaceutical compositions for preventing or treating cataracts or floaters, method for its preparation, as well as methods for preventing or treating cataracts or floating opacities. Pharmaceutical composition for preventing or treating cataracts or floaters, wherein the pharmaceutical composition contains the following components: a compound of Formula I, hydroxypropyl methylcellulose, benzalkonium chloride, a pH regulator and a solubiliser;

where the pharmaceutical composition contains the components in the following ratios by weight: from 0.01 to 4 parts of the compound of Formula I, from 2 to 12 parts of hydroxypropyl methylcellulose, from 0.05 to 0.06 parts of benzalkonium chloride, from 1 to 20 parts of a pH regulator, and from 10 to 50 parts of a solubiliser, and the pH of the pharmaceutical composition ranges from 6 to 8, where the pH regulator is selected from boric acid and borax, and the solubiliser is selected from the group consisting of polysorbate-80, glycerine, hydrogenated castor oil-RH40. Pharmaceutical composition for preventing or treating cataracts or floaters, where the pharmaceutical composition contains the components in the following weight ratios: 2 parts of a compound of Formula I, 6 parts of hydroxypropyl methylcellulose, 25 parts of glycerol and 0.05 parts of benzalkonium chloride, or 2 parts of a compound of Formula I, 6 parts of hydroxypropyl methylcellulose, 10 parts of hydrogenated castor oil-RH40, 40 parts of polysorbate-80, 25 parts of glycerine and 0.05 parts of benzalkonium chloride. Method for preparing said pharmaceutical composition involving: uniform mixing of compound of formula I, hydroxypropyl methylcellulose, benzalkonium chloride, pH regulator and a solubiliser by weight in accordance with cl. 1 for preparing a pharmaceutical composition, where the pH regulator is selected from boric acid and borax, and the solubiliser is selected from a group consisting of polysorbate-80, glycerol, hydrogenated castor oil-RH40. Method of preventing or treating cataracts or floaters involves administering one of the above pharmaceutical compositions to a patient four times a day in dose of 2 drops each time.

EFFECT: use of the group of inventions enables to obtain a composition which is stable when exposed to light and high temperature, as well as preparation of a drug for preventing or treating cataracts or floaters based on the disclosed composition.

12 cl, 2 tbl, 5 ex