FIELD: chemistry.
SUBSTANCE: invention relates to a compound having general formula (I)
where R is a hydrogen atom or C1-C6 alkyl group; R1 and R2, each independently represent a hydrogen atom or C1-C6 alkyl group; or R1 and R2 are combined with the carbon atom to which they are bonded to form a monocyclic carbocycle containing 4–5 ring-forming carbon atoms; R3, R4 and R6, each independently represent a hydrogen atom, a halogen atom, C1-C6 alkyl group or C1-C6 alkoxy group; R5 is C1-C6 alkyl group; A has a structure represented by formula (II)
R7 and R8, each independently represent a hydrogen atom or C1-C6 alkyl group; or R7 and R8 are combined with the carbon atom to which they are bonded to form a monocyclic carbocycle containing 3 ring-forming carbon atoms; ring B is a bicyclic ring optionally substituted with 1 to 3 substituents independently selected from the group consisting of a halogen atom, C1-C6 alkyl group and C1-C6 alkoxy group; said bicyclic ring is selected from a saturated or unsaturated 9–10-membered bicyclic ring optionally containing 1–2 heteroatoms selected from an oxygen atom, a sulphur atom and a nitrogen atom, in addition to carbon atoms; and the symbol 
is the point of attachment to the remaining part of the molecule, or a pharmaceutically acceptable salt thereof, as well as to a pharmaceutical composition, application, agent and method for preventing, relieving and/or treating a disease whose symptoms are relieved by Keap1 inhibition.
EFFECT: disclosed are benzotriazole derivatives for preventing, relieving and/or treating a disease whose symptoms are relieved by Keap1 inhibition.
18 cl, 7 tbl
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| NEW AMINOARYL DERIVATIVE SUITABLE AS A DIACYLGLYCEROLACYL TRANSFERASE 2 INHIBITOR AND ITS APPLICATION | 2020 |
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| BICYCLIC LACTAMS AND METHODS FOR USE THEREOF | 2016 |
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RU2716136C2 |
| 5-SUBSTITUTED INDAZOLE AS KINASE INHIBITORS | 2008 |
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| DERIVATIVES OF CYCLOHEXANE OR TETRAHYDROPYRANE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, OR HYDRATES, OR SOLVATES OF THESE COMPOUNDS, OR THEIR SALTS, INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS AND FUNGICIDE AGENT | 1992 |
|
RU2084439C1 |
| COMPOUND WITH A CYCLIC STRUCTURE | 2018 |
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RU2795119C2 |
| HER2 MUTATION INHIBITORS | 2022 |
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RU2834124C2 |
