COMPOUND WITH SUCCESSIVE ARICYCLIC STRUCTURE, POSSESSING ACTIVITY OF INHIBITING ACYCLOENZYME A DIACYLGLYCEROLACYLTRANSFERASE (DGAT1) Russian patent published in 2015 - IPC C07D401/04 C07D233/64 C07D401/10 C07D401/14 C07D403/04 C07D403/10 A61K31/4164 A61K31/44 A61K31/497 A61K31/506 A61P3/04 A61P3/06 A61P3/10 A61P9/10 A61P9/12 A61P43/00 

FIELD: chemistry.

SUBSTANCE: invention relates to heterocyclic compound of formula or to its pharmaceutically acceptable salt, where Alk represents linear C_1-6 alkylene group, branched C_1-6 alkylene group or C_1-6 alkylene group, which has ring structure, where part of carbon atoms, constituting ring structure can be optionally substituted with oxygen atom, in ring X, X¹ represents N or CR^X1, X² represents N or CR^X2, X³ represents CR^X3, X⁴ represents N or CR^X4, where R^X1, R^X2, R^X3 and R^X4 each independently represents hydrogen atom; linear or branched C_1-6alkyl group; linear or branched C_1-6alcoxygroup; or halogen atom, in ring Y, Y¹ represents CR^Y1, Y² represents N or CR^Y2, Y³ represents N or CR^Y3, Y⁴ represents N or CR^Y4, R^Y1, R^Y2, R^Y3 and R^Y4 each independently represents hydrogen atom; linear or branched C_1-6alkyl group, which can be substituted with halogen atom(s); C_3-7alkyl group, which has ring structure; linear or branched C_1-6alkoxygroup; halogen atom or cyanogroup, in ring Z, R^Z represents linear or branched C_1-6alkyl group, which can be substituted with halogen atom(s), or C_3-7alkyl group, which has ring structure, which can be substituted with halogen atom(s). Invention also relates to particular compounds, DGAT1 inhibitor based on formula (I) compound, application of formula (I) compound, method of prevention or treatment of diseases, mediated by DGAT1 inhibition.

EFFECT: obtained are novel compounds, possessing useful biological activity.

19 cl, 19 tbl, 149 ex