DUAL TARGETING COMPOUND FOR FIBROBLAST ACTIVATION PROTEIN (FAP) AND INTEGRIN αβ, METHOD FOR PRODUCTION AND USE THEREOF Russian patent published in 2025 - IPC A61K47/64 C07K7/64 A61K51/08 A61K38/12 A61P35/00 A61P17/02 A61P29/00 A61P9/10

Abstract RU 2838403 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to a dual targeting compound capable of acting on fibroblast activation protein (FAP) and integrin α_vβ₃. Also disclosed is a radionuclide-labelled dual-targeting compound based on a target compound, method for production thereof and use in diagnosis or treatment of diseases characterized by high expression of fibroblast activation protein (FAP) and/or integrin α_vβ₃.

EFFECT: compound of the present invention and its radionuclide marker can synergistically affect a FAP target and an integrin target α_vβ₃ in tumours.

10 cl, 60 dwg, 2 tbl, 138 ex

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RU 2 838 403 C1

Authors

Chen, Xiaoyuan

Xu, Pengfei

Wu, Xiaoming

Guo, Zhide

Yang, Qingbao

Wen, Xuejun

Dates

2025-04-16—Published

2023-09-26—Filed