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1 324 249

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IPC

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Application

3858816/04, 1984-12-29

(22)

Actual filing date

1984-12-29

(45)

Published

1994-03-15

(72)

Inventor

Nedospasov A.A.Nezavibat'Ko V.N.Kuznetsov N.V.

(73)

Holder

Institut Molekuljarnoj Genetiki Ran

1-(AMINOACYL)AMINONAPHTHALENE-5-SULFOACIDS AS A SUBSTRATE FOR DETERMINATION OF AMIDASE ACTIVITY OF ENZYMES, AND A METHOD OF THEIRS SYNTHESIS Russian patent published in 1994 - IPC

Abstract SU 1324249 A3

FIELD: organic chemistry. SUBSTANCE: synthesis is carried out from 1-aminonaphthalene-5-sulfoacid salt and corresponding amino acid with protected amino-group in the medium of dimethylformamide in the presence of condensing agent (dicyclohexylcarbodiimide) and hydroxybenzotriazole for 12-24 h. The end product is isolated by precipitation with organic solvent, extraction, chromatography and crystallization. Protective carbobenzoxy-group is removed by treatment with HBr in acetic acid. Synthesized compounds do not show harmful effect as compared with 2-naphthalene that enables to measure in aqueous medium. EFFECT: detection of compounds indicated above. 4 cl, 1 dwg, 2 tbl

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SU 1 324 249 A3

Authors

Nedospasov A.A.

Nezavibat'Ko V.N.

Kuznetsov N.V.

Dates

1994-03-15—Published

1984-12-29—Filed

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