FIELD: medicine, biotechnology. SUBSTANCE: method involves the growing of culture A. globiformia 193 in fermenter by cell immobilization in polyacrylamide gel with cross-linking agent. Gel granules with immobilized culture were used for prednisolone preparing. Granules were put into reactor of industrial type together with microcrystalline hydrocortisone, and dehydrogenation is carried out at filling coefficient 0.8-0.9 at the stirring of reaction mixture by circulation through the phase partition surface liquid-air at the definite regime parameters. EFFECT: increased yield of the end product.
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