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2 156 302

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Application

98123648/13, 1998-12-28

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Start date

1998-12-28

(22)

Actual filing date

1998-12-28

(45)

Published

2000-09-20

(72)

Inventor

Sukhodol'Skaja G.V.Donova M.V.Nikolaeva V.M.Koshcheenko K.A.Dovbnja D.V.Khomutov S.M.Gulevskaja S.A.

(73)

Holder

Donova Marina ViktorovnaSukhodol'Skaja Galina Viktorovna

METHOD OF PRODUCING 1,2-DEHYDRODERIVATIVES OF 4-DELTA-3-KETO-STEROIDS Russian patent published in 2000 - IPC

Abstract RU 2156302 C1

FIELD: organic chemistry, steroids, biotechnology. SUBSTANCE: 1,2-dehydroderivatives of 4-delta-3-ketosteroids are produced by transformation of 4-delta-3-ketosteroids, for example, hydrocortisone, Reichstein's substance "S", androstendione and others by bacterium Arthrobacter globiformis in the presence of water-soluble chemically modified derivatives of beta-cyclodextrin (hydroxypropylcyclodextrin, methylcyclodextrin and others). Use of water-soluble derivatives of beta-cyclodextrin ensures to carry out the transformation of 4-delta-3-ketosteroids at high (above 20 g/l) substrate loading, at complete selective conversion of substrate to the end product and high rates of process. Biosynthesized indicated steroid compounds are used in medicine. EFFECT: improved method of production, increased yield of steroids. 15 ex

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RU 2 156 302 C1

Authors

Sukhodol'Skaja G.V.

Donova M.V.

Nikolaeva V.M.

Koshcheenko K.A.

Dovbnja D.V.

Khomutov S.M.

Gulevskaja S.A.

Dates

2000-09-20—Published

1998-12-28—Filed