FIELD: medicine, organic chemistry. SUBSTANCE: desired product is prepared by interaction of 3-mercapto-1,2,4-triazino[5,6-b]indole and hydrochloride of 2-dipropylaminoehyl chloride. The process is carried out in aqueous medium in the presence of NaOH. Thus prepared precipitate is treated with alcohol hydrogen chloride. Desired product having essential formula C11H24ClN5S is prepared at yield 93 %. EFFECT: creates novel more active compound. 1 tbl
| Title |
Year |
Author |
Number |
| 3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE HYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING |
1989 |
- Tomchin A.B.
- Spivakova R.P.
- Smirnov A.V.
|
SU1623156A1 |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-8-METHOXY-1,2,4-TRIAZINO-[5,6-B]- INDOLE DIHYDROCHLORIDE ENHANCING RESISTANCE TO HYPERTHERMIA |
1988 |
- Tomchin A.B.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Krjukova L.M.
- Zelenin K.N.
|
SU1552605A1 |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-8-METHYL-1,2,4-TRIAZINO-[5,6-B]- INDOLE DIHYDROCHLORIDE ENHANCING RESISTANCE TO HYPERTHERMIA |
1988 |
- Tomchin A.B.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Kravchenko V.V.
|
SU1547279A1 |
| 5-(2-MORPHOLINOETHYL) -3-N-BUTYLTHIO -5H-1,2,4- TRIAZINO- [5,6-B] INDOLE HYDROCHLORIDE SHOWING CAPABILITY TO RECOVERY FUNCTIONS OF ORGANISM AND NORMALIZE BEHAVIORAL ACTIVITY AT THE EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Grechko A.T.
- Tomchin A.B.
- Lomov O.P.
- Smirnov A.V.
|
SU1764297A1 |
| DIHYDROCHLORIDE OF 8-METHOXY-3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO(5,6-B)INDOLE HAVING ACTIVITY AGAINST HYPOXIA AND PROTECTING ACTIVITY AGAINST STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Basieva T.S.
- Katkov V.F.
- Urjupov O.Ju.
|
SU1231835A1 |
| (1,2,4-TRIAZINO-[5,6-B]-INDOLYL-3-THIO)-ACETIC ACID HYDRAZIDE ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIARRHYTHMIC ACTIVITY |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Alekseev V.V.
- Vinogradov V.M.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Skorobogatov V.I.
|
SU1487415A1 |
| 8-AMINO-3- (2-DIETHYLAMINOETHYLTHIO) -1,2,4-TRIAZINO (5,6-B)- INDOL HYDROCHLORIDE ACCELERATING RECOVERY OF ENCEPHALON FUNCTIONS IN EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Tomchin A.B.
- Grechko A.T.
- Smirnov A.V.
|
SU1786803A1 |
| 8-METHYL-3-(2-MORPHOLINOETHYLTHIO)-5H-1,2,4-TRIAZINO[5,6-B]INDOLE DIHIDROCHLORIDE HYDRATE SHOWING CAPABILITY TO ACCELERATE RECOVERY OF CEREBRUM FUNCTION IN THE EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Grechko A.T.
- Tomchin A.B.
- Lomov O.P.
- Smirnov A.V.
|
RU1764298C |
| AMIDE OF (1,2,4-TRIAZINO[5,6-B]INDOLYL-3-THIO)ACETIC ACID WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND HAS ACTIVITY AGAINST HYPOXIA |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Vinogradov V.M.
- Spivakova R.P.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1487413A1 |
| 3-ETHYLTHIO-5-(2-MORPHOLINO)-ETHYL-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE SHOWING ANTIINFLAMMATORY, ANTIHYPOXIC ACTIVITY AND CAPABILITY TO INCREASE RESISTANCE TO REPEATED CRANIOCEREBRAL TRAUMA |
1982 |
- Tomchin A.B.
- Ponomareva M.M.
- Pastushenkov A.L.
- Gatchina T.A.
- Balljuzek F.V.
- Seleznev L.G.
- Stepnykh Ju.P.
- Pastushenkov V.L.
- Nalimov Ju.D.
- Pastushenkov L.V.
|
SU1059866A1 |
