MALEIC ACID TRIFLUOROACETYLHYDRAZIDE SHOWING ANTIVIRAL ACTIVITY Russian patent published in 1995 - IPC

Abstract SU 1547253 A1

FIELD: organic chemistry. SUBSTANCE: product: maleic acid trifluoroacetylhydrazide. Synthesis is carried out by reaction of trifluoroacetic acid hydrazide and maleic anhydride in ethyl acetate medium. Yield is 82% m. p. is 178-179 C, empirical formula is C6H5F3N2O4, toxicity LD50= 1600 mg/kg, efficacy index is 41 and 50 as compared with that for remantadin and adapromin. Synthesized compound shows antiviral activity against influenza viruses type A, B and parainfluenza 3 type and can be used in medicine. EFFECT: synthesis of new active compounds of class indicated above. 3 tbl

Similar patents SU1547253A1

Title Year Author Number
MALEIC ACID O-AMINOBENZOYL HYDRAZIDE HYDROCHLORIDE HAVING ACTIVITY WITH RESPECT TO PATHOGEN OF 3-TYPE PARAGRIPPE 1990
  • Koz'Minykh V.O.
  • Andrejchikov Ju.S.
  • Il'Enko V.I.
  • Kalinina N.A.
SU1743149A1
MALEIC ACID PHENYLACETYLHYDRAZIDE SHOWING ANTIVIRAL ACTIVITY AGAINST PC-INFECTION PATHOGEN 1990
  • Koz'Minykh V.O.
  • Andrejchikov Ju.S.
  • Il'Enko V.I.
  • Guseva V.M.
SU1743150A1
BENZYLIDENE HYDRAZIDE OF P-TOLUENE PYRORACEMIC ACID POSSESSING ANTIVIRUS ACTIVITY 1989
  • Koz'Minykh V.O.
  • Andrejchikov Ju.S.
  • Il'Enko V.I.
  • Guseva V.M.
  • Kalinina N.A.
SU1623134A1
2-METHYL-5-METHOXY-3-METHOXALYLACETOBENZOFURAN POSSESSING ANTIVIRUS ACTIVITY AGAINST VIRUS OF INFLUENZA OF A- AND B- TYPE 1991
  • Andrejchikov Ju.S.
  • Miljutin A.V.
  • Velezheva V.S.
  • Il'Enko V.I.
RU2032683C1
AMBENE ETHYL ESTER GLUTAMATE SHOWING ANTIVIRAL ACTIVITY AGAINST INFLUENZA VIRUSES OF SEROTYPE A AND B 1990
  • Shevchenko L.I.
  • Lozitskij V.P.
  • Tatarova T.A.
  • Kulaeva L.N.
  • Fedchuk A.S.
  • Lozinskij M.O.
  • Girlja Ju.I.
RU2030393C1
METHOD OF INFLUENZA VIRUSES BIOLOGICAL ACTIVITY INCREASE 0
  • Skripchenko Georgij Stepanovich
  • Ponomarenko Andrej Ivanovich
  • Rybakova Tatyana Mikhajlovna
  • Bezbrozh Igor Moiseevich
SU1806189A3
SODIUM SALT 5-METHYL-6-NITRO-1,2,4-TRIAZOLE[1,5-a]PYRIMIDINE-7-ONE DIHYDRATE 2006
  • Chupakhin Oleg Nikolaevich
  • Rusinov Vladimir Leonidovich
  • Ulomskij Evgenij Nartsissovich
  • Charushin Valerij Nikolaevich
  • Petrov Aleksandr Jur'Evich
  • Kiselev Oleg Ivanovich
RU2330036C1
HYDRAZIDE GLUTAMATE OF P-AMINOMETHYLBENZOIC ACID SHOWING ANTIVIRAL ACTIVITY WITH RELATION TO INFLUENZA VIRUS SEROTYPE A AND B 1988
  • Shevchenko L.I.
  • Lozitskij V.P.
  • Lozinskij M.O.
  • Tatarova T.A.
SU1531420A1
2-R-4-(ALLYLOXYMETHYL)-6-NITRO-1,2,4-TRIASOLO[5,1-C]-1,2,4-TRIAZIN-7(4H)-ONS AND 2-R-4-(PROPARGYLOXYMETHYL)-6-NITRO-1,2,4-TRIASOLO[5,1-C]-1,2,4-TRIAZIN7(4H)-ONS, POSSESSING ANTI-VIRAL ACTIVITY 2006
  • Chupakhin Oleg Nikolaevich
  • Rusinov Vladimir Leonidovich
  • Ulomskij Evgenij Nartsissovich
  • Deev Sergej Leonidovich
  • Rusinova Larisa Ivanovna
  • Shestakova Tat'Jana Sergeevna
  • Kiselev Oleg Ivanovich
  • Deeva Ehlla Germanovna
RU2340614C2
2-METHYLTHIO-6-NITRO-1,2,4-TRIAZOLO[5,1-C]-1,2,4-TRIAZINE-7(4H)-ONE SODIUM SALT DIHYDRATE POSSESSING ANTIVIRAL ACTIVITY 2005
  • Chupakhin Oleg Nikolaevich
  • Rusinov Vladimir Leonidovich
  • Ulomskij Evgenij Nartsissovich
  • Charushin Valerij Nikolaevich
  • Petrov Aleksandr Jur'Evich
  • Kiselev Oleg Ivanovich
RU2294936C1

SU 1 547 253 A1

Authors

Andrejchikov Ju.S.

Koz'Minykh V.O.

Il'Enko V.I.

Platonov V.G.

Kalinina N.A.

Dates

1995-10-20Published

1988-07-26Filed