FIELD: organic chemistry. SUBSTANCE: product: maleic acid trifluoroacetylhydrazide. Synthesis is carried out by reaction of trifluoroacetic acid hydrazide and maleic anhydride in ethyl acetate medium. Yield is 82% m. p. is 178-179 C, empirical formula is C6H5F3N2O4, toxicity LD50= 1600 mg/kg, efficacy index is 41 and 50 as compared with that for remantadin and adapromin. Synthesized compound shows antiviral activity against influenza viruses type A, B and parainfluenza 3 type and can be used in medicine. EFFECT: synthesis of new active compounds of class indicated above. 3 tbl
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METHOD OF INFLUENZA VIRUSES BIOLOGICAL ACTIVITY INCREASE | 0 |
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HYDRAZIDE GLUTAMATE OF P-AMINOMETHYLBENZOIC ACID SHOWING ANTIVIRAL ACTIVITY WITH RELATION TO INFLUENZA VIRUS SEROTYPE A AND B | 1988 |
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2-R-4-(ALLYLOXYMETHYL)-6-NITRO-1,2,4-TRIASOLO[5,1-C]-1,2,4-TRIAZIN-7(4H)-ONS AND 2-R-4-(PROPARGYLOXYMETHYL)-6-NITRO-1,2,4-TRIASOLO[5,1-C]-1,2,4-TRIAZIN7(4H)-ONS, POSSESSING ANTI-VIRAL ACTIVITY | 2006 |
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2-METHYLTHIO-6-NITRO-1,2,4-TRIAZOLO[5,1-C]-1,2,4-TRIAZINE-7(4H)-ONE SODIUM SALT DIHYDRATE POSSESSING ANTIVIRAL ACTIVITY | 2005 |
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RU2294936C1 |
Authors
Dates
1995-10-20—Published
1988-07-26—Filed