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2 030 393

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IPC

(21) (22)

Application

4803325/04, 1990-01-23

(22)

Actual filing date

1990-01-23

(45)

Published

1995-03-10

(72)

Inventor

Shevchenko L.I.Lozitskij V.P.Tatarova T.A.Kulaeva L.N.Fedchuk A.S.Lozinskij M.O.Girlja Ju.I.

(73)

Holder

Institut Organicheskoj Khimii An Ukrainy

AMBENE ETHYL ESTER GLUTAMATE SHOWING ANTIVIRAL ACTIVITY AGAINST INFLUENZA VIRUSES OF SEROTYPE A AND B Russian patent published in 1995 - IPC

Abstract RU 2030393 C1

FIELD: organic chemistry. SUBSTANCE: synthesis is carried out by reaction of ambene ethyl ester with glutamic acid in water medium at boiling. Yield is 98%, m. p. is 179-181 C, empirical formula is C₁₅H₂₂N₂O₆, toxicity LD₅₀ = 3080 mg/kg. Activity with respect to influenza viruses A and B is by 30 and 7.5-fold more as compared with that of ambene hydrazide glutamate. EFFECT: synthesis of substance of class indicated above showing increased activity. 2 tbl

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RU 2 030 393 C1

Authors

Shevchenko L.I.

Lozitskij V.P.

Tatarova T.A.

Kulaeva L.N.

Fedchuk A.S.

Lozinskij M.O.

Girlja Ju.I.

Dates

1995-03-10—Published

1990-01-23—Filed