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1 547 275

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A1

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IPC

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Application

4492731/04, 1988-07-29

(22)

Actual filing date

1988-07-29

(45)

Published

1996-10-27

(72)

Inventor

Pozharskij A.F.Smirnova L.P.Lebedeva A.I.Kujantseva A.M.

3-METHYL-6-[1-ETHYL-2-α-(5-NITROFURFURYLIDENE)]-HYDRAZINO- URACIL SHOWING ACTION AGAINST STAPHYLOCOCCI AND BACILLI Russian patent published in 1996 - IPC

Abstract SU 1547275 A1

FIELD: heterocyclic compounds. SUBSTANCE: product: 3-methyl- 6-[1-ethyl-2--α--(5-nitrofurfurylidene)] -hydrazinouracil. Synthesis is carried out by reaction of 3-methyl-6-(1-ethyl)-hydrazinouracil with 5-nitrofurfurol in ethanol medium. Yield is 80%, m. p. is 269-270 C, empirical formula is -α-; C12H13N5O5 value at oral and intraperitoneal administration is 4800 and 2150 mg/kg, respectively. Activity of new compound exceeds that of furacillin by 2-4-fold. Synthesized compound can be used in medicine. EFFECT: enhanced and selective antimicrobial activity, low toxicity. 1 tbl

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SU 1 547 275 A1

Authors

Pozharskij A.F.

Smirnova L.P.

Lebedeva A.I.

Kujantseva A.M.

Dates

1996-10-27—Published

1988-07-29—Filed

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