FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: (1,2,4-triazino-[5,6-b] -indolyl-3-thio)-acetic acid hydrazide. Synthesis is carried out by reaction of (1,2,4-triazino-[5,6-b]-indolyl-3-thio)-acetic acid with hydrazine hydrate in alcohol at boiling for 3 hr. Yield is 72%, m. p. is 258 C, empirical formula is C11H10N6OS. Under conditions of superheating climate (40 C, 30% humidity) new compound increases resistance to hyperthermia at 60% protection degree for animals, its antiarrhythmic activity is 2-fold as compared with trimecain (by duration) at lower doses (by 2-10 times). Synthesized compound can be used in medicine. EFFECT: new activity of compound indicated above. 2 tbl
| Title |
Year |
Author |
Number |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-8-METHOXY-1,2,4-TRIAZINO-[5,6-B]- INDOLE DIHYDROCHLORIDE ENHANCING RESISTANCE TO HYPERTHERMIA |
1988 |
- Tomchin A.B.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Krjukova L.M.
- Zelenin K.N.
|
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1981 |
- Tomchin A.B.
- Vinogradov V.M.
- Poskalenko A.N.
- Ponomareva M.M.
- Basieva T.S.
|
SU1032758A1 |
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1987 |
- Tomchin A.B.
- Zhukova T.I.
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1987 |
- Tomchin A.B.
- Zhukova T.I.
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- Vinogradov V.M.
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| METHOD OF CORRECTING FAILURES IN REPRODUCTIVE ORGANS CAUSED BY HIGH TEMPERATURE |
2009 |
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|
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| 3-(2-DIMETHYLAMINOETHYLTHIO)-8-METHYL-1,2,4-TRIAZINO-[5,6-B]- INDOLE DIHYDROCHLORIDE ENHANCING RESISTANCE TO HYPERTHERMIA |
1988 |
- Tomchin A.B.
- Katkov V.F.
- Sumina Eh.N.
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- Kravchenko V.V.
|
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| (1,2,4-TRIAZINO-[5,6-B]-INDOLYL-3-THIO)-ACETIC ACID DIETHYLAMIDE SHOWING ANTIHYPOXIC ACTIVITY |
1989 |
- Zhukova T.I.
- Kuznetsova T.A.
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- Smirnov A.V.
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1989 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Urjupov O.Ju.
- Kostycheva M.V.
- Smirnov A.V.
|
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1991 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Urjupov O.Ju.
- Katkov V.F.
- Mostycheva M.V.
- Smirnov A.V.
- Pavlovskij V.F.
|
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| 3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE DIHYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING, ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIHYPOXIC ACTIVITY |
1987 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Tonkopij D.V.
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- Sumina Eh.N.
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|
SU1498021A1 |
