(1,2,4-TRIAZINO-[5,6-B]-INDOLYL-3-THIO)-ACETIC ACID HYDRAZIDE ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIARRHYTHMIC ACTIVITY Russian patent published in 1996 - IPC

Abstract SU 1487415 A1

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: (1,2,4-triazino-[5,6-b] -indolyl-3-thio)-acetic acid hydrazide. Synthesis is carried out by reaction of (1,2,4-triazino-[5,6-b]-indolyl-3-thio)-acetic acid with hydrazine hydrate in alcohol at boiling for 3 hr. Yield is 72%, m. p. is 258 C, empirical formula is C11H10N6OS. Under conditions of superheating climate (40 C, 30% humidity) new compound increases resistance to hyperthermia at 60% protection degree for animals, its antiarrhythmic activity is 2-fold as compared with trimecain (by duration) at lower doses (by 2-10 times). Synthesized compound can be used in medicine. EFFECT: new activity of compound indicated above. 2 tbl

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SU 1 487 415 A1

Authors

Tomchin A.B.

Zhukova T.I.

Kuznetsova T.A.

Alekseev V.V.

Vinogradov V.M.

Katkov V.F.

Sumina Eh.N.

Katkova E.B.

Skorobogatov V.I.

Dates

1996-09-10Published

1987-08-03Filed