FIELD: bioorganic chemistry. SUBSTANCE: desired product is prepared by reaction p-chlorophenol with activated by mixture of triphenylphosphine, 2, 2′- dithiopyridine and 1-methylimidazole suitable N, 3′-o-diacyldesoxynucleotide. Reaction is carried out in dimethylformamide containing triethyamine, its quantity being equivalent p-chlorophenol. Reaction mixture is sustained within 40-70 min at room temperature. Reaction time is 1-1.2 h; desired product yield is up to 80% . EFFECT: increases yield, simplifies the process, decreases reaction time. 2 tbl
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