FIELD: chemistry.
SUBSTANCE: method includes modification of a carrier, which is represented by amine-containing nanoparticles of silicon dioxide with a size up to 24 nm, by processing the latter with N-hydroxysuccinimide ether of aliphatic azido acid, then obtaining modified nucleosidetriphosphate (pppN) by processing the latter with a mixture of triphenylphosphine/dithiodipyridine with further incubation of the formed active derivative pppN with 3-propinyloxypropylamine and further immobilisation of the modified pppN on the obtained asidomodified nanoparticles for 2-4 hours.
EFFECT: reduction of the method duration and an increased quality of the target product.
3 cl, 4 dwg, 9 ex
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