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SU

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1 589 585

(13)

A1

(51)

IPC

(21) (22)

Application

4609185/04, 1988-11-22

(22)

Actual filing date

1988-11-22

(45)

Published

1996-06-10

(72)

Inventor

Saratikov A.S.Novozheeva T.P.Akhmedzhanov R.R.Vasil'Eva V.P.Khalfina I.L.

DERIVATIVES OF 2,2'-DIPHENIC ACID MONOANILIDES SHOWING ENZYME-INDUCING ACTIVITY WITH RELATION TO HEPATIC CYTOCHROME P-450-DEPENDENT MONOOXYGENASE SYSTEM Russian patent published in 1996 - IPC

Abstract SU 1589585 A1

FIELD: organic chemistry. SUBSTANCE: product: carboxylic acid amides, in part, derivatives of 2,2'-diphenic acid monoanilides of the formula where R - 2-Cl, 3-Cl, 3-, 4-Br, 4-J, 4-F. Synthesis is carried out by acylation of halogen-substituted 2,2'-diphenic acid anilines. New compounds decrease hexenal sleep duration, increase microsomal protein and cytochromes P-450 content in liver, accelerate metabolism of substrates - amidopyrine and aniline, value LD50 = 640-1200 mg/kg (for phenobarbital value LD50 = 320 mg/kg). Synthesized compounds show enzyme-inducing activity with relation to hepatic cytochrome P-450-dependent monooxygenase system. EFFECT: detection of compounds indicated above. 2 tbl

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SU 1 589 585 A1

Authors

Saratikov A.S.

Novozheeva T.P.

Akhmedzhanov R.R.

Vasil'Eva V.P.

Khalfina I.L.

Dates

1996-06-10—Published

1988-11-22—Filed

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