FIELD: organic chemistry, triazinoindole derivatives. SUBSTANCE: product: (1,2,4-triazino-[5,6-b] -indolyl-3-thio)-acetic acid diethylamide. Synthesis is carried out by addition of monochloroacetic acid diethylamide solution to 3-mercapto-1,2,4-triazino-[5,6-b]-indole solution in the presence of sodium hydroxide solution. Mixture is kept at room temperature, precipitate is filtered off, washed with water, cooled alcohol and (1,2,4-triazino-[5,6-b] -indolyl-3-thio)-acetic acid diethylamide is isolated as the base. Synthesized compound is purified by recrystallization from isobutyl alcohol. Yield of the end product is 66%, m. p. is 209 C, empirical formula is C15H17N5OS, toxicity LD50 = 3400 mg/kg, active maximal dose is 25 mg/kg, therapeutic index is 136. EFFECT: new compounds showing enhanced activity and lowered toxicity. 1 tbl
| Title |
Year |
Author |
Number |
| (1,2,4-TRIAZINO-[5,6-B]-INDOLYL-3-THIO)-ACETIC ACID N-(2-HYDROXYETHYL)-AMIDE SHOWING ANTIHYPOXIC ACTIVITY AND RECOVERING FUNCTIONAL ELECTRIC BRAIN ACTIVITY |
1991 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Urjupov O.Ju.
- Katkov V.F.
- Mostycheva M.V.
- Smirnov A.V.
- Pavlovskij V.F.
|
SU1804067A1 |
| 3-(3-DIMETHYLAMINOPROPYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE SHOWING ANTIHYPOXIC ACTIVITY |
1989 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Urjupov O.Ju.
- Kostycheva M.V.
- Smirnov A.V.
|
SU1598431A1 |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE PROTECTING AGAINST ACUTE TOXIC LUNG EDEMA |
1989 |
- Tomchin A.B.
- Kropotov A.V.
- Butakov V.N.
- Urjupov O.Ju.
- Kostycheva M.V.
- Marysheva V.V.
|
SU1674533A1 |
| 3-(MORPHOLINOCARBONYLMETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE ENHANCING RESISTANCE TO HYPERCAPNIC HYPOXIA |
1989 |
- Turzhova E.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Tomchin A.B.
|
SU1596719A1 |
| AMIDE OF (1,2,4-TRIAZINO[5,6-B]INDOLYL-3-THIO)ACETIC ACID WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND HAS ACTIVITY AGAINST HYPOXIA |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Vinogradov V.M.
- Spivakova R.P.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1487413A1 |
| 3-(PIPERIDINOCARBONYLMETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE SHOWING ANTIHYPOXIC ACTIVITY AND PROTECTING AGAINST ACUTE TOXIC LUNG EDEMA |
1989 |
- Zhukova T.I.
- Kuznetsova T.A.
- Tomchin A.B.
- Urjupov O.Ju.
- Kostycheva M.V.
- Kropotov A.V.
- Butakov V.N.
|
SU1681504A1 |
| 3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE DIHYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING, ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIHYPOXIC ACTIVITY |
1987 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Tonkopij D.V.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1498021A1 |
| 3-ETHYLTHIO-5-(2-MORPHOLINO)-ETHYL-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE SHOWING ANTIINFLAMMATORY, ANTIHYPOXIC ACTIVITY AND CAPABILITY TO INCREASE RESISTANCE TO REPEATED CRANIOCEREBRAL TRAUMA |
1982 |
- Tomchin A.B.
- Ponomareva M.M.
- Pastushenkov A.L.
- Gatchina T.A.
- Balljuzek F.V.
- Seleznev L.G.
- Stepnykh Ju.P.
- Pastushenkov V.L.
- Nalimov Ju.D.
- Pastushenkov L.V.
|
SU1059866A1 |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-8-METHYL-1,2,4-TRIAZINO-[5,6-B]- INDOLE DIHYDROCHLORIDE ENHANCING RESISTANCE TO HYPERTHERMIA |
1988 |
- Tomchin A.B.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Kravchenko V.V.
|
SU1547279A1 |
| (1,2,4-TRIAZINO-[5,6-B]-INDOLYL-3-THIO)-ACETIC ACID HYDRAZIDE ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIARRHYTHMIC ACTIVITY |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Alekseev V.V.
- Vinogradov V.M.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Skorobogatov V.I.
|
SU1487415A1 |
