FIELD: organic chemistry. SUBSTANCE: product: (1,2,4-triazino-[5,6-b] -indolyl-3-thio)-acetic acid N-(2-hydroxyethyl)-amide of the formula 
. Empirical formula is C13H13N5O2S, yield is 67%, m. p. is 226 C. Reagent 1: 3-mercapto-1,2,4-triazino-[5,6-b]-indole. Reagent 2: N-(2-hydroxyethyl)-α-chloroacetamide. Reaction condition: in sodium hydroxide aqueous solution. EFFECT: improved method of synthesis. 2 tbl
| Title |
Year |
Author |
Number |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE PROTECTING AGAINST ACUTE TOXIC LUNG EDEMA |
1989 |
- Tomchin A.B.
- Kropotov A.V.
- Butakov V.N.
- Urjupov O.Ju.
- Kostycheva M.V.
- Marysheva V.V.
|
SU1674533A1 |
| DERIVATIVES OF 4-ACETYLIMIDAZO-[4,5-B]-INDOLE-2-THIONE SHOWING ANTIHYPOXIC AND VIRUS-INHIBITING ACTIVITY WITH RESPECT TO HORSE VENEZUELAN ENCEPHALOMYELITIS AND METHOD OF THEIR SYNTHESIS |
1991 |
- Velezheva V.S.
- Mel'Man A.I.
- Tomchin A.B.
- Katkov V.F.
- Smushkevich Ju.I.
- Smirnov A.V.
- Fomina A.N.
- Nikolaeva I.S.
- Il'Ina M.G.
|
RU2091382C1 |
| (1,2,4-TRIAZINO-[5,6-B]-INDOLYL-3-THIO)-ACETIC ACID DIETHYLAMIDE SHOWING ANTIHYPOXIC ACTIVITY |
1989 |
- Zhukova T.I.
- Kuznetsova T.A.
- Tomchin A.B.
- Urjupov O.Ju.
- Kostycheva M.V.
- Smirnov A.V.
|
SU1665679A1 |
| 3-(PIPERIDINOCARBONYLMETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE SHOWING ANTIHYPOXIC ACTIVITY AND PROTECTING AGAINST ACUTE TOXIC LUNG EDEMA |
1989 |
- Zhukova T.I.
- Kuznetsova T.A.
- Tomchin A.B.
- Urjupov O.Ju.
- Kostycheva M.V.
- Kropotov A.V.
- Butakov V.N.
|
SU1681504A1 |
| 3-(3-DIMETHYLAMINOPROPYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE SHOWING ANTIHYPOXIC ACTIVITY |
1989 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Urjupov O.Ju.
- Kostycheva M.V.
- Smirnov A.V.
|
SU1598431A1 |
| 3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE DIHYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING, ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIHYPOXIC ACTIVITY |
1987 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Tonkopij D.V.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1498021A1 |
| DIHYDROCHLORIDE OF 8-METHOXY-3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO(5,6-B)INDOLE HAVING ACTIVITY AGAINST HYPOXIA AND PROTECTING ACTIVITY AGAINST STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Basieva T.S.
- Katkov V.F.
- Urjupov O.Ju.
|
SU1231835A1 |
| AMIDE OF (1,2,4-TRIAZINO[5,6-B]INDOLYL-3-THIO)ACETIC ACID WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND HAS ACTIVITY AGAINST HYPOXIA |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Vinogradov V.M.
- Spivakova R.P.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1487413A1 |
| (1,2,4-TRIAZINO-[5,6-B]-INDOLYL-3-THIO)-ACETIC ACID HYDRAZIDE ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIARRHYTHMIC ACTIVITY |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Alekseev V.V.
- Vinogradov V.M.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Skorobogatov V.I.
|
SU1487415A1 |
| 3-ETHYLTHIO-5-(2-MORPHOLINO)-ETHYL-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE SHOWING ANTIINFLAMMATORY, ANTIHYPOXIC ACTIVITY AND CAPABILITY TO INCREASE RESISTANCE TO REPEATED CRANIOCEREBRAL TRAUMA |
1982 |
- Tomchin A.B.
- Ponomareva M.M.
- Pastushenkov A.L.
- Gatchina T.A.
- Balljuzek F.V.
- Seleznev L.G.
- Stepnykh Ju.P.
- Pastushenkov V.L.
- Nalimov Ju.D.
- Pastushenkov L.V.
|
SU1059866A1 |
