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1 640 973

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A1

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Application

4722868/04, 1989-07-26

(22)

Actual filing date

1989-07-26

(45)

Published

1996-09-27

(72)

Inventor

Tomchin A.B.Smirnov A.V.Gajvoronskaja V.V.Okovityj S.V.Katkov V.F.

N,N'-DI-(3-OXO-2-INDOLYL)-S-BENZYLISOTHIOUREA PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION Russian patent published in 1996 - IPC

Abstract SU 1640973 A1

FIELD: heterocyclic compounds. SUBSTANCE: product: N,N'-di-(3-oxo-2-indolyl)-S-benzylisothiourea. Synthesis is carried out from S-benzylisothiourea hydrochloride, sodium acetate trihydrate and isatin O-methyl ether. Yield is 58.5%, m. p. is 222 C. empirical formula is CCl4., C24H16N4O2S. = 3000 mg/kg. The use of new compound decreases the level alanine aminotransferase in serum blood by 2.3-fold that is index of protecting effect against hepatocyte membrane damage by LD50. Synthesized compound protects liver against poisoning with CCl4. EFFECT: enhanced effectiveness of synthesized compound. 1 tbl

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SU 1 640 973 A1

Authors

Tomchin A.B.

Smirnov A.V.

Gajvoronskaja V.V.

Okovityj S.V.

Katkov V.F.

Dates

1996-09-27—Published

1989-07-26—Filed

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