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1 640 983

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Application

4719088/04, 1989-07-14

(22)

Actual filing date

1989-07-14

(45)

Published

1996-09-10

(72)

Inventor

Zhukova T.I.Tomchin A.B.Kuznetsova T.A.Smirnov A.V.Gajvoronskaja V.V.Okovityj S.V.Katkov V.F.

3-[2-(2-OXO-1-PYRROLIDINYL)-ETHYLTHIO]-1,2,4-TRIAZINO-[5,6-B]- INDOLE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION Russian patent published in 1996 - IPC

Abstract SU 1640983 A1

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: 3-[2-(2-oxo-1-pyrrolidinyl)-ethylthio-1,2,4-triazino-[5,6-b] - indole that protects liver against intoxication with CCl4. Synthesis is carried out from 3-mercapto-1,2,4-triazino-[5,6-b] -indole in NaOH and N-2-chloroethylpyrrolidone at 70 C for 5 hr. Yield is 92.9%, m. p. is 221 C, empirical formula is C15H15N5OS, value LD50 = 3200 mg/kg. EFFECT: detection of compounds showing enhanced hepatoprotective activity. 1 tbl

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SU 1 640 983 A1

Authors

Zhukova T.I.

Tomchin A.B.

Kuznetsova T.A.

Smirnov A.V.

Gajvoronskaja V.V.

Okovityj S.V.

Katkov V.F.

Dates

1996-09-10—Published

1989-07-14—Filed

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