FIELD: medicine. SUBSTANCE: invention relates to heterocyclic substances, more particularly N-(1-acetylinedol-3-one-2- yl) thiocarbamide liver from toxic effect of CCl4. Synthesis is carried out by reaction of 1-acetyl-2- aminoindoxyl hydrochloride with potassium thiocyanate in glacial acetic acid at 120 C. Yield 71% empirical formula: C11H11N8O2S bilirubin content is by 2.5 times lower and alanine transferase level is by 1.5 times lower in blood serum as compared with mixture of riboxin and potassium orotate at toxicity of PC50=710 ± 85 mg/kg. EFFECT: improved properties of the title compound.
| Title |
Year |
Author |
Number |
| 3-(2-DIPROPYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION |
1991 |
- Tomchin A.B.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Nagornev S.N.
|
SU1829357A1 |
| 8-AMINO-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION AND PROCESS ACCELERATING AFTER PHYSICAL LOADING |
1991 |
- Tomchin A.B.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Spivakova R.P.
|
SU1809608A1 |
| 5-(2-MORPHOLINOETHYL)-3-PROPYLTHIO-1,2,4-TRIAZINO-[5,6-B]-INDOLE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION |
1989 |
- Tomchin A.B.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Katkov V.F.
- Nagornev S.N.
|
SU1626646A1 |
| 3-[3-(4-METHYLPIPERAZINE-1-YL)-PROPYLTHIO]-1,2,4-TRIAZINO- [5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION |
1991 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
|
SU1829358A1 |
| N,N'-DI-(3-OXO-2-INDOLYL)-S-BENZYLISOTHIOUREA PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION |
1989 |
- Tomchin A.B.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Katkov V.F.
|
SU1640973A1 |
| 3-[2-(2-OXO-1-PYRROLIDINYL)-ETHYLTHIO]-1,2,4-TRIAZINO-[5,6-B]- INDOLE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION |
1989 |
- Zhukova T.I.
- Tomchin A.B.
- Kuznetsova T.A.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Katkov V.F.
|
SU1640983A1 |
| HYDROBROMIDE OF 1-ACETYL-2-ISOTHIOUREIDO-3-INDOLINONE PROTECTED LIVER AGAINST POISONING OF CARBON TETRACHLORIDE |
1991 |
- Velezheva V.S.
- Mel'Man A.I.
- Tomchin A.B.
- Marysheva V.V.
- Smirnov A.V.
- Okovityj S.V.
- Gajvoronskaja V.V.
|
RU2009127C1 |
| 4-ACETYL-3-BENZYL-2-METHYLTHIOIMIDAZO (4,5 ) INDOLE PROTECTING LIVER AGAINST POISONING OF CARBON TETRACHLORIDE |
1991 |
- Velezheva V.S.
- Mel'Man A.I.
- Tomchin A.B.
- Okovityj S.V.
- Smirnov A.V.
- Gajvoronskaja V.V.
|
RU2009141C1 |
| USING 2-AMINO-4-ACETYLTHIAZOLO[5,4-b]INDOLE FOR LIVER PROTECTION AGAINST POISONING WITH CARBON TETRACHLORIDE |
2004 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
|
RU2309743C2 |
| 2-AMINO-4-ACETYLTHIAZOLO[5,4-B]INDOLE HYDROBROMIDE PROTECTING LIVER AGAINST POISONING WITH CARBON TETRACHLORIDE AND A METHOD OF ITS SYNTHESIS |
1992 |
- Velezheva V.S.
- Mel'Man A.I.
- Tomchin A.B.
- Smirnov A.V.
- Okovityj S.V.
- Gajvoronskaja V.V.
|
RU2076867C1 |
