FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: 5-(2-morpholinoethyl)-3-propylthio-1,2,4-triazino-[5,6-b] -indole. Corresponding compound unsubstituted at position 5 is converted to its Na-salt which is treated with 2-morpholinoethyl-bromide hydrobromide. Hydrobromic acid is neutralized with sodium hydroxide and obtained product as a free base is converted to the end hydrochloride by treatment with gaseous HCl. Empirical formula is C18H23N5OS•HCl, value LD50 = 560 ± 60 mg/kg. EFFECT: detection of compounds showing activity indicated above. 1 tbl
| Title |
Year |
Author |
Number |
| 3-[3-(4-METHYLPIPERAZINE-1-YL)-PROPYLTHIO]-1,2,4-TRIAZINO- [5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION |
1991 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
|
SU1829358A1 |
| N-(1-ACETYLINEDOL-3-ONE-2-YL)-THIOCARBAMIDE PROTECTING LIVER FROM TOXIC EFFECT OF CARBON TETRACHLORIDE |
1990 |
- Velezheva V.S.
- Mel'Man A.I.
- Tomchin A.V.
- Smirnov A.S.
- Gajvoronskaja V.V.
- Okovityj S.V.
|
SU1736149A1 |
| 8-AMINO-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION AND PROCESS ACCELERATING AFTER PHYSICAL LOADING |
1991 |
- Tomchin A.B.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Spivakova R.P.
|
SU1809608A1 |
| 3-[2-(2-OXO-1-PYRROLIDINYL)-ETHYLTHIO]-1,2,4-TRIAZINO-[5,6-B]- INDOLE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION |
1989 |
- Zhukova T.I.
- Tomchin A.B.
- Kuznetsova T.A.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Katkov V.F.
|
SU1640983A1 |
| 3-(2-DIPROPYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION |
1991 |
- Tomchin A.B.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Nagornev S.N.
|
SU1829357A1 |
| N,N'-DI-(3-OXO-2-INDOLYL)-S-BENZYLISOTHIOUREA PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION |
1989 |
- Tomchin A.B.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Katkov V.F.
|
SU1640973A1 |
| 5-(2-MORPHOLINOETHYL) -3-N-BUTYLTHIO -5H-1,2,4- TRIAZINO- [5,6-B] INDOLE HYDROCHLORIDE SHOWING CAPABILITY TO RECOVERY FUNCTIONS OF ORGANISM AND NORMALIZE BEHAVIORAL ACTIVITY AT THE EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Grechko A.T.
- Tomchin A.B.
- Lomov O.P.
- Smirnov A.V.
|
SU1764297A1 |
| 3-(2-DIETHYLAMINOETHYLTHIO)-5-(2-MORPHOLINOETHYL)-1,2,4- TRIAZINO(5,6-b)INDOL DIHYDROCHLORIDE POSSESSING STRESS-PROTECTIVE ACTIVITY |
1982 |
- Vinogradov V.M.
- Tomchin A.B.
- Katkova E.B.
- Katkov V.F.
|
SU1154907A1 |
| 4-ACETYL-3-BENZYL-2-METHYLTHIOIMIDAZO (4,5 ) INDOLE PROTECTING LIVER AGAINST POISONING OF CARBON TETRACHLORIDE |
1991 |
- Velezheva V.S.
- Mel'Man A.I.
- Tomchin A.B.
- Okovityj S.V.
- Smirnov A.V.
- Gajvoronskaja V.V.
|
RU2009141C1 |
| 2-METHYLTHIOPYRIMIDO[4,5-b]INDOLE PROTECTING LIVER FROM POISONING WITH CARBON TETRACHLORIDE |
2004 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
|
RU2300534C2 |
