FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: 6,14-endoetheno- or 6,14-endoethano-7α-(1-hydroxy-1-methyl-1-alkyl-C1-C4-methyl)-- tetrahydrothebains. Synthesis is carried out by reaction of 6,14-endoethano- or 6,14-endoetheno-7α-acetyltetrahydrothebain with the corresponding alkylmagnesium halide excess in inert organic solvent in the presence of 0.5-1.5 mole amount of potassium tert.-butylate. Yield of the end products is 80-95%. Synthesized compounds can be used as analgetic agents. EFFECT: increased yield of the end products. 1 tbl
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Year |
Author |
Number |
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0 |
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