2-METHYL-3-ACYL-5-HYDROXYBENZOFURANS AS SEMIPRODUCTS FOR SYNTHESIS OF 2-METHYL-3-ACYL-4-DIALKYLAMINOMETHYL-5-HYDROXYBENZOFURAN HYDROCHLORIDES SHOWING LOCAL ANESTHETIC ACTIVITY Russian patent published in 1994 - IPC

Abstract SU 1732653 A1

FIELD: organic chemistry. SUBSTANCE: products: substituted benzofurans, 2-methyl-3-acyl-5-hydroxybenzofurans of the general formula where , a) R₁=R₂=H; R₃=F, Br, OCH₃; b) R₁=H, R₂=R₃=OCH₃; c) R₁=R₃=OCH₃, R₂=H; d) R₁=R₂=R₃=OCH₃. Synthesis is carried out by condensation of substituted acetophenones with diethylacetal following by treatment with p-benzoquinone in the medium of acetic acid. Yield, %; m. p. C; empirical formula: a) 39.2, 187-188, C₁₆H₁₁BrO₃; b) 42, 191-192, C₁₆H₁₁FO₃; c) 32.5, 169-170, C₁₇H₁₄O₄; d) 32.5, 204-206, C₁₈H₁₆O₅; e) 40.7, 180-182, C₁₈H₁₆O₅; f) 36, 171-173, C₁₉H₁₈O₆. Synthesized compounds can be used in medicine. EFFECT: synthesis of new semiproducts indicated above. 2 tbl

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SU 1 732 653 A1

Authors

Mukhanova T.I.

Granik V.G.

Zinov'Eva R.A.

Dates

1994-11-30—Published

1990-03-29—Filed