FIELD: medicine. SUBSTANCE: product: 5-(2-morpholinoethyl)-3-n-butylthio-5H-1,2,4-triazino-(5,6-b)-indole hydrochloride, gross-formula is C19H26ClN5OS, yield is 40%, m. p. is 202 C. Reagent 1: 3-n-butylthio-5H-1,2,4-triazino-(5,6-b)-indole. Reagent 2: 2-morpholinoethyl bromide. Reaction conditions: in the medium of anhydrous DMFA in the presence of NaOH at 120 C. Free base formed is treated with gaseous HCl in the medium of iso-C3H7OH. EFFECT: improved method of synthesis. 2 tbl, 1 ex
| Title |
Year |
Author |
Number |
| 8-METHYL-3-(2-MORPHOLINOETHYLTHIO)-5H-1,2,4-TRIAZINO[5,6-B]INDOLE DIHIDROCHLORIDE HYDRATE SHOWING CAPABILITY TO ACCELERATE RECOVERY OF CEREBRUM FUNCTION IN THE EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Grechko A.T.
- Tomchin A.B.
- Lomov O.P.
- Smirnov A.V.
|
RU1764298C |
| 8-AMINO-3- (2-DIETHYLAMINOETHYLTHIO) -1,2,4-TRIAZINO (5,6-B)- INDOL HYDROCHLORIDE ACCELERATING RECOVERY OF ENCEPHALON FUNCTIONS IN EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Tomchin A.B.
- Grechko A.T.
- Smirnov A.V.
|
SU1786803A1 |
| 3-(2-DIETHYLAMINOETHYLTHIO)-5-(2-MORPHOLINOETHYL)-1,2,4- TRIAZINO(5,6-b)INDOL DIHYDROCHLORIDE POSSESSING STRESS-PROTECTIVE ACTIVITY |
1982 |
- Vinogradov V.M.
- Tomchin A.B.
- Katkova E.B.
- Katkov V.F.
|
SU1154907A1 |
| 5-(2-MORPHOLINOETHYL)-3-PROPYLTHIO-1,2,4-TRIAZINO-[5,6-B]-INDOLE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION |
1989 |
- Tomchin A.B.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Katkov V.F.
- Nagornev S.N.
|
SU1626646A1 |
| 3-ETHYLTHIO-5-(2-MORPHOLINO)-ETHYL-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE SHOWING ANTIINFLAMMATORY, ANTIHYPOXIC ACTIVITY AND CAPABILITY TO INCREASE RESISTANCE TO REPEATED CRANIOCEREBRAL TRAUMA |
1982 |
- Tomchin A.B.
- Ponomareva M.M.
- Pastushenkov A.L.
- Gatchina T.A.
- Balljuzek F.V.
- Seleznev L.G.
- Stepnykh Ju.P.
- Pastushenkov V.L.
- Nalimov Ju.D.
- Pastushenkov L.V.
|
SU1059866A1 |
| 8-AMINO-3-(2-DIPROPYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-5,6-INDOLE HYDROCHLORIDE ACCELERATING RECOVERY OF BRAIN FUNCTIONS AT THE EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
0 |
- Tomchin Aleksandr Beniaminovich
- Grechko Aleksandr Timofeevich
- Smirnov Aleksandr Vladimirovich
|
SU1825794A1 |
| HYDROCHLORIDE OF 3-(2-DIPROPYLAMINOETHYLTHIO)-1,2,4-TRIAZINO[5,6-B)-INDOLE WHICH INCREASES RESISTANCE AGAINST HYPERTERMIA |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Zvezdina N.S.
- Vinogradov V.M.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Andreev V.B.
|
SU1483895A1 |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE PROTECTING AGAINST ACUTE TOXIC LUNG EDEMA |
1989 |
- Tomchin A.B.
- Kropotov A.V.
- Butakov V.N.
- Urjupov O.Ju.
- Kostycheva M.V.
- Marysheva V.V.
|
SU1674533A1 |
| 3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE HYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING |
1989 |
- Tomchin A.B.
- Spivakova R.P.
- Smirnov A.V.
|
SU1623156A1 |
| 8-AMINO-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION AND PROCESS ACCELERATING AFTER PHYSICAL LOADING |
1991 |
- Tomchin A.B.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Spivakova R.P.
|
SU1809608A1 |
