FIELD: organic chemistry, 1,2,4-triazino-[5,6-b]-indole derivatives. SUBSTANCE: product: 3-(2-dimethylaminoethylthio)-1,2,4-triazino-[5,6-b] -indolyl-5- acetamide. Synthesis is carried out by reaction of 3-(2-dimethylaminoethylthio)-1,2,4-triazino-[5,6-b] -indole with α-chloroacetamide in anhydrous dimethylformamide. Yield is 50%, m. p. is 146 C, empirical formula is C15H18N6OS, toxicity LD50 = 1720 mg/kg, therapeutic index is 275.2. New compound can protect living organism against acute toxic lung edema while 3-(3-dimethylaminopropylthio)-1,2,4-triazino-[5,6-b] -indole shows antihypoxic action only. Synthesized compound can be used in medicine. EFFECT: new compound showing specific activity. 2 tbl
| Title |
Year |
Author |
Number |
| (1,2,4-TRIAZINO-[5,6-B]-INDOLYL-3-THIO)-ACETIC ACID N-(2-HYDROXYETHYL)-AMIDE SHOWING ANTIHYPOXIC ACTIVITY AND RECOVERING FUNCTIONAL ELECTRIC BRAIN ACTIVITY |
1991 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Urjupov O.Ju.
- Katkov V.F.
- Mostycheva M.V.
- Smirnov A.V.
- Pavlovskij V.F.
|
SU1804067A1 |
| 3-(3-MORPHOLINO-2-OXYPROPYLTHIO)-1,2,4-TRIAZINO[5,6-B]INDOLE WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD |
1986 |
- Tomchin A.B.
- Spivakova R.P.
- Vinogradov V.M.
- Timofeeva E.B.
|
SU1420901A1 |
| 3-(PIPERIDINOCARBONYLMETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE SHOWING ANTIHYPOXIC ACTIVITY AND PROTECTING AGAINST ACUTE TOXIC LUNG EDEMA |
1989 |
- Zhukova T.I.
- Kuznetsova T.A.
- Tomchin A.B.
- Urjupov O.Ju.
- Kostycheva M.V.
- Kropotov A.V.
- Butakov V.N.
|
SU1681504A1 |
| 3-ETHYLTHIO-5-(2-MORPHOLINO)-ETHYL-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE SHOWING ANTIINFLAMMATORY, ANTIHYPOXIC ACTIVITY AND CAPABILITY TO INCREASE RESISTANCE TO REPEATED CRANIOCEREBRAL TRAUMA |
1982 |
- Tomchin A.B.
- Ponomareva M.M.
- Pastushenkov A.L.
- Gatchina T.A.
- Balljuzek F.V.
- Seleznev L.G.
- Stepnykh Ju.P.
- Pastushenkov V.L.
- Nalimov Ju.D.
- Pastushenkov L.V.
|
SU1059866A1 |
| 8-AMINO-3- (2-DIETHYLAMINOETHYLTHIO) -1,2,4-TRIAZINO (5,6-B)- INDOL HYDROCHLORIDE ACCELERATING RECOVERY OF ENCEPHALON FUNCTIONS IN EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Tomchin A.B.
- Grechko A.T.
- Smirnov A.V.
|
SU1786803A1 |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-8-METHYL-1,2,4-TRIAZINO-[5,6-B]- INDOLE DIHYDROCHLORIDE ENHANCING RESISTANCE TO HYPERTHERMIA |
1988 |
- Tomchin A.B.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Kravchenko V.V.
|
SU1547279A1 |
| 3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE HYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING |
1989 |
- Tomchin A.B.
- Spivakova R.P.
- Smirnov A.V.
|
SU1623156A1 |
| 3-(3-DIMETHYLAMINOPROPYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE SHOWING ANTIHYPOXIC ACTIVITY |
1989 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Urjupov O.Ju.
- Kostycheva M.V.
- Smirnov A.V.
|
SU1598431A1 |
| 8-BROMO-3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO(5,6-B)INDOLE WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND PROLONGED STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Spivakova R.P.
- Krylova I.M.
- Katkova E.B.
|
SU1223608A1 |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-8-METHOXY-1,2,4-TRIAZINO-[5,6-B]- INDOLE DIHYDROCHLORIDE ENHANCING RESISTANCE TO HYPERTHERMIA |
1988 |
- Tomchin A.B.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Krjukova L.M.
- Zelenin K.N.
|
SU1552605A1 |
