N'-BIS- (ETHYLENEIMINO)PHOSPHONYL- N''- ARYLUREAS SHOWING ANTIBLASTIC ACTIVITY, N'-DICHLOROPHOSPHONYL -N''- ARYLUREAS FOR SYNTHESIS OF N'-BIS- (ETHYLENEIMINO)PHOSPHONYL -N''-ARYLUREAS AND FLUORO-CONTAINING ANILINES FOR SYNTHESIS OF N'- DICHLOROPHOSPHONYL -N''-ARYLUREAS Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product 1: compound of the general formula (I) where . These compounds increase survival life span of animals as compared with known standard N′-bis- (ethyleneimino)phosphonyl-N′, -3-(2-chloro -1,1,2-trifluoroethyoxy) phenylurea and show decreased toxicity. Product 2: compounds of the formula (II) XC₆H₄-NH₂, where X 4-S-C₃F₇, 3-O-CF₂-CHF-GF₃. Product 3: compounds of the formula (III) XC₆H₄-NH-C(O)-NH-P(O)-(Cl)₂, where X as for compound of the formula (I). Reaction conditions for compounds of the formula (II): condensation of p-aminothiophenol with heptafluoropolypropyl iodide in liquid ammonia and UV-light following by ammonia removing, treatment with KOH and extraction with ether; perfluoropropylene bubbling through the aqueous solution of 3-acetylaminophenol and triethylamine at 90 C following by treatment with HCl at cooling and extraction with benzene. Reaction conditions for compounds of the formula (III) addition of amine solution of the formula (II) to isocyanatophosphoric acid dichloroanhydride in ether. Reaction conditions for compounds of the formula (I): aziridine treatment with compound of the formula (II) in the medium of CHCl₃ in the presence of triethylamine at 4-6 C. Synthesized compounds were used for synthesis of medicinal agents. EFFECT: improved method of synthesis. 4 cl, 1 tbl