METHOD OF PRODUCING PYRAZOLE-PURIDINE DERIVATIVE OR ITS SALT Russian patent published in 1994 - IPC

FIELD: medicine. SUBSTANCE: desired product has common formula 1 CHCH-CHCH-N-CCR₂-CR₁N where R₁ is phenyl, R₂ is group having 2-7 formula, R₃ is alkyl, hydroxyalkyl, alkoxyalkyl, alkoxycarbonyl, carbomoylalkyl or N, N-dialkyl ( or they forms together puridine ring); R₄ is carboxyalkyl or alkoxycarbonylalkyl; R₅ - H, carboxy - or cyano-group, alkoxycarbonyl; R₆ is alkoxycarbonylalkyl; R₇ - alkyl, carboxyalkyl, alkoxycarbonylalkyl; R₈ is alkyl, carboxyalkyl or alkoxycarbonyl; R₉ is carboxyalkyl or alkoxy-carbonylalkyl; R₁₀ is H or OH; in all these cases lower alkyls being used. Reagent 1 is product having formula 1 where instead of R₂ are used groups having 2-7 formulae without any groups at corresponding nitrogen atoms from R₃-R₁₀, or salt of this product. Reagent 2 is compound having formula QY where Q is R₃-R₉, Y is removing group. Desired product is prepared by interaction of these two reagents. If if is necessary lower alkyl group is removed of thus prepared product in which R₃-R₉ and each of them are (lower ) alkoxycarbonyl(lower)alkyl. Structural formulae 2-7 are given. EFFECT: improves efficiency of the method.