METHOD OF PRODUCING ANTITUMOR PLATINUM COMPLEXES Russian patent published in 1994 - IPC

FIELD: medicine. SUBSTANCE: desired product has formula 1 where A and B are individual amines or they together form compound having NH₂ formula where Y is carbocyclic group containing 5-8 atoms in ring, or A and B together represent group having formula 11 where Z is group having formula 111 where n= 0 or 1; NH₂ is hydrogen, R′,R²-alkyl or C₁-C₄-alkyl substituted by C₁-C₄-alkoxy or alkoxyalkoxy group containing 2-5 carbon atoms and Z means group having formula IV where X means bond or C₁-C₄ group, CH₂-alkyl substituted by OH group or by alkoxyalkoxyalkoxy group containing 3-7 carbon atoms or silyloxy group substituted trialkyl R″-C₁-C₄ group or (C₁-C₄) group or OPO(OR³)₂ group where R-C₁-C₄-alkyl. Reagent 1 is compound having formula V where A and B are as mentioned above, R^a-OH or ON₂O. Reagent 2 is compound having formula VI or formula VII where D is hydrogen or alkali metal, R′,R²,R″ are as mentioned above. Compounds having I-VII formulae are given in specification. EFFECT: improved efficiency of the method. 8 tbl