METHOD OF ISOXAZOLE DERIVATIVES SYNTHESIS Russian patent published in 1994 - IPC

FIELD: organic chemistry. SUBSTANCE: products of formula (I) , where R₁ - hydrogen atom, halogen or alkyl with 1-4 carbon atoms; R₂ - hydrogen atom, alkyl with 1-4 carbon atoms, phenyl unsubstituted or substituted with at least one substituent, or heterocycle with 5-6 atoms in the ring, in which 1 - nitrogen or sulfur or R₁ and R₂ - a group of formula -CR₄=CR₅-CR₆=CR₇- ,, where R₄-R₇ - hydrogen atom, halogen, alkyl with 1-4 carbon atoms, alkoxy-group with 1-4 carbon atoms; R₃ - piperidyl unsubstituted or substituted with alkyl with 1-6 carbon atoms at nitrogen atom or quinuclidinium. Reagent 1: compound of formula N-O-C(R₂)C(R₁)CX. Reagent 2: J-R₃, where X and J - removal groups. Synthesized compounds are used in medicine. EFFECT: improved method of synthesis. 9 tbl