FIELD: organic chemistry. SUBSTANCE: product: derivatives of taxol of formula (I), where R1 and R2 - H or the group of formula (III)
, where n= 1-3; R3 and R4 is C1-C3-alkyl at condition that at least one of R1 and R2 is not hydrogen atom. Reagent 1: taxol. Reagent 2: compound of the general formula (II)
, where R3 and R4 as indicated above. Process conditions: in the presence of condensing agent and catalyst (the presence of latter does not obligatory). At the ratio of compound (II) and taxol 1:1 2-substituted compound of formula (I) is prepared, where R1 is a group of formula (III) and R2 - H. At the case of synthesis of 2,7-di(substituted) of compound of formula (I), where R1 and R2 - a group of formula (III), is reacted with compound of formula (II). If necessary, 2,7-di(substituted) compounds of formula (I) is split at pH 7-7.4, and 7-substituted compound of formula (I) is prepared, where R1 - H, and R2 - a group of formula (III). Compound of formula (I) shows high antitumor activity at the dose 1.88-7.50 mg/kg and water solubility. Synthesized compounds are used in medicine. EFFECT: enhanced antitumor activity. 6 cl, 2 tbl
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