METHOD OF PYRIMIDINE DERIVATIVE SYNTHESIS Russian patent published in 1994 - IPC

FIELD: organic chemistry. SUBSTANCE: product: derivatives of pyrimidine of the general formula , where any groups of K, L and M are nitrogens, and a third one is a group -CH= ; C - hydrogen or halogen; X - hydrogen, halogen, unsubstituted one; C₁-C₄-alkyl or substituted with halogen, hydroxyl or cyano-group, C₂-C₄-alkenylhydroxy-(C₂-CH)-group, phenyl, cyanothiocyanate-, nitro-group, group -NR¹R², where R¹ and R² are hydrogen or C₁-C₄-alkyl, C₁-C₄-alkylcarbonylamino-, azido-group, C₁-C₄-alkoxyl, phenoxy-, benzylhydroxy-group, C₁-C₄-alkoxycarbonylmethyl, C₁-C₄-alkanoylhydroxy-, C₁-C₄-alkylsulfonylhydroxy-, C₁-C₄-alkylsulfonyl-group, formyl, C₁-C₄-alkanoyl, hydroxyimino-C₁-C₄-alkyl-group, carbamoyl, thiocarbamoyl or CH₃O₂CC=CHOCH₃-group; Y - halogen, C₁-C₄-alkyl, C₁-C₄-alkoxyl, nitro-, di-C₁-C₄-alkylamino-group or hydrogen; or X and Y in the case when are in ortho-position with regard to each to other, together with phenyl-ring to which they are linked form naphthalene ring; A - halogen, hydrogen, C₁-C₄-alkyl, or C₁-C₄-alkoxyl. Reagent 1: compound of formula . Reagent 2: . Reaction conditions: in dimethylformamide, at 0-110 C. Synthesized compounds are used in agriculture. EFFECT: improved method of synthesis. 5 tbl