FIELD: organic chemistry. SUBSTANCE: product - macrolide compounds of the formula (I) given in the invention description. Reagent 1: compound of the formula (II) given in description. Reagent 2: NH2OR3 where R3 - as indicated in description. Reaction conditions: temperature is 10-80 C for 1-24 h in the medium of inert solvent following by isolation of the end product of the formula (I). Synthesized compounds are used in agriculture and cause lethality of ticks at the range 92-100%. EFFECT: improved method of synthesis, increased effectiveness of the end products. 1 tbl
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