FIELD: medicine. SUBSTANCE: novel compounds of the present invention have general formula: 
wherein R1 is group of formula: -OR3 and R3 are each hydrogen, alkyl or alkoxy; -NHCH(R6)COR7 in which R6 is hydrogen or alkyl and R7 is alkyl; -NHCH(R6)COOR8 in which R8 is alkyl or -NHCH(R6)CONR9R10 in which R9 and R10 are each hydrogen or alkyl, or NR9R10 together form heterocyclic group and R2 is hydrogen, alkyl or aralkyl. Compounds have inhibitory activity to collagenase type 1V due to which fact they are useful as angiogenesis inhibitors, cancer infiltration and cancer methastases. EFFECT: improved properties. 23 cl, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
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