FIELD: chemical technology. SUBSTANCE: product of the formula (I) 
. ((+)I): [α]2
Д
5+ 189°(C= 0,50, is ethanol); ((-)I): [α]2
Д
5- 189°(C= 0,050, is ethanol). Reagent 1: compound of the formula (± )-I. Reagent 2: optically active carboxylic acid of the formula (II) 
. Process conditions: process is carried out at -20-100 C following by treatment of prepared crystalline diastereomeric salt or its solvate-base at -20-50 C. Compound (+)-I is more active as compared with compound of the formula (-)-I. Separated compounds are used in medicine. EFFECT: improved method of separation of compounds indicated above. 4 cl, 2 tbl
| Title |
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Number |
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