METHOD OF SYNTHESIS OF DELMOPINOL AND ISOXAZOLEIMIDINE DERIVATIVES Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: products: mono- or polyunsaturated compound of the formula (II) CH₂= CH-R where R 2-propylpentyl nonobligatory containing one internal double bond, or 2-substituted 2-propylpentyl where substituent is removal group at position 2 is interacted with morpholine nitron of the formula (III) , and compound of the formula (IV) is synthesized where R as indicated above as a mixture of syn- and anti-isomers followed by reductive ring disclosure in synthesized compound. Prepared mixture of compounds of the formula (Va) , (Vb) and (Vc) where R 2-propylpentyl is treated with chlorinating agent. Prepared after chlorination mixture of compound of the formula (Va) with chloro-analogues of compounds (Vb) and (Vc) is subjected for dechlorination. Prepared compound of the formula (Va) is N-alkylated, and the end product is isolated. EFFECT: improved method of synthesis. 7 cl, 1 tbl