FIELD: chemistry.
SUBSTANCE: invention relates to pharmaceutical chemistry, specifically to a method for synthesis of 1-nitroxyadamantane, an intermediate product in synthesis of 1-adamantane carboxylic acid, a fundamental intermediate product in synthesis of remantadin antiviral drug. According to the disclosed method, adamantine is added to 10-15% solution of ammonium nitrate in 98% nitric acid, taken in amount of 4.5-5.6 weight parts per 1 part of adamantine at temperature 3-5°C and then held for 1.5 hours at 22-25°C, poured on ice and the reaction product is separated.
EFFECT: output of 1-nitroxyadamantane is equal to 90-91% in accordance with the disclosed method.
1 cl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 1-ADAMANTANE CARBOXYLIC ACID | 2009 |
|
RU2412930C1 |
| METHOD OF SYNTHESIS OF 1-(1-AMINOETHYL)-ADAMANTANE HYDROCHLORIDE | 1997 |
|
RU2118313C1 |
| METHOD OF PREPARING 1-ADAMANTANECARBOXYLIC ACID | 1997 |
|
RU2124497C1 |
| METHOD OF PRODUCING POLYBASIC CARBOXYLIC ACIDS OF ADAMANTANE SERIES | 2012 |
|
RU2489417C1 |
| METHOD OF PRODUCING TRIBASIC CARBOXYLIC ACIDS OF ADAMANTANE SERIES | 2014 |
|
RU2569376C1 |
| METHOD OF OBTAINING HYDROCHLORIDES OF ADAMANTANE AMINES | 2013 |
|
RU2541545C2 |
| METHOD OF SYNTHESIS OF 2-METHYL-4(5)-NITRO-IMIDAZOLE | 2001 |
|
RU2198877C1 |
| 0 |
|
SU524791A1 | |
| METHOD FOR PRODUCTION OF DERIVATIVES OF 2-R-4(5)-NITRO IMIDAZOLES | 1992 |
|
RU2049780C1 |
| METHOD OF PRODUCING 2-(2-HYDROXY)ADAMANTYLALKYL(ARYL)KETONES | 2009 |
|
RU2420511C2 |
