METHOD OF SYNTHESIS OF 3-(1-THIAZOLIDINYLBUTYL-4-PIPERAZINYL)-1H-INDAZOLES Russian patent published in 1995 - IPC

Abstract RU 2038355 C1

FIELD: organic chemistry. SUBSTANCE: product: 3-(1-thiazolidinylbutyl-4-piperazinyl)-1H-indazoles of the general formula (I) where R1 and R2 independently each of other hydrogen, lower alkyl or R1 and R2 together with carbon to which they are bound form cyclopentane or cyclohexane ring; R3 and R4 independently each of other hydrogen or lower alkyl; R5 hydrogen or lower alkyl; X hydrogen or halogen, or their pharmaceutically acid-additive salts. Reagent 1: derivative of 4-thiazolodinone of the formula (II) where R1, R2, R3 and R4 as indicated above. Reagent 2: 3-(1-piperazinyl)-1H-indazole of the formula (III) where X as indicated above. Reaction conditions: in the medium of organic solvent, at heating in atmosphere of inert gas. In the case of synthesis of compounds where R5 lower alkyl compound of the formula (I) where R3 hydrogen is alkylated. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 1 tbl

Similar patents RU2038355C1

Title Year Author Number
3-(THIAZOLIDENYLBUTYL-4-PIPERAZINYL)-1H-INDAZOLES 1993
  • Nikolas Dzh.Khrib[Us]
  • Dzhozef T.Strupzhevski[Us]
  • Dzhon G.Dzherkehk[Us]
  • Kennet Bordo[Us]
RU2105765C1
METHOD FOR PRODUCTION OF SUBSTITUTED N-(ARYL OXYALKYL)-HETEROARYL PIPERIDINE OR HETEROARYL PIPERAZINE 1990
  • Dzhozef Tomas Strupchevski[Us]
  • Grover Kleveland Khelslej[Us]
  • Julin Chiang[Us]
  • Kennet Dzh.Bordeo[Us]
RU2062776C1
BENZISOTHIAZOLE- OR BENZISOXAZOLE-3-CARBOXAMIDES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING ANTIPSYCHOTIC ACTIVITY 1992
  • Nikolas Dzh.Khrib[Us]
  • Dzhon G.Dzhurkak[Us]
RU2039057C1
DERIVATIVES OF N-(ARYLOXYALKYL)-HETEROARYLPIPERIDINE AND HETEROARYLPIPERAZINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF 1990
  • Dzhozef Tomas Strupchevski
  • Grover Kleveland Khelslej
  • Julin Chiang
  • Kennet Dzh. Bordeo
RU2147583C1
1-[PYRIDO(3,4-B)-1,4-OXAZINYL-4-YL]-1H-INDOLES, METHOD OF THEIR SYNTHESIS, COMPOSITION ON THEIR BASIS AND DERIVATIVE OF N-(4-PYRIDINYL)-1H-INDOLE-1-AMINE 1992
  • Richard Charl'Z Ehffland[Us]
RU2042680C1
[(ARYLALKYLPIPERIDINYL-4-YL)-METHYL]-2A,3,4,5-TETRAHYDRO-1-ONES OR THEIR ACID-ADDITIVE SALTS AND A METHOD OF THEIR PREPARING 1992
  • Rehjmond V.Kosli Ml.[Us]
  • Bettina Shpal'[Us]
RU2043989C1
SUBSTITUTED BENZOTHIENYLPIPERAZINES, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION 1996
  • Nikolas Dzh.Rib
  • Dzhon G.Jurchak
  • Abdul E.Mertlib
RU2157371C2
METHOD OF SYNTHESIS OF 6-FLUORO-1,2-BENZISOTHIAZOLE, ORTHO-SUBSTITUTED PHENACYL-DERIVATIVE, AND A METHOD OF ITS SYNTHESIS 1992
  • Dehvid M.Fink[Us]
  • Dzhozef T.Strupchevski[Us]
RU2027704C1
SUBSTITUTED TETRAHYDRO-, OR HEXAHYDROCYCLOPENT/B/ INDOLES OR THEIR PHARMACEUTICALLY ACCEPTABLE ADDITIVE SALTS AND METHOD FOR THEIR PRODUCTION 1992
  • Khelen Khu Ong[Us]
  • Dzherard Dzhozef O"Malli[Us]
  • Majkl Klejton Merrimen[Us]
  • Mark Gabriel' Palermo[Us]
RU2077530C1
METHOD OF SYNTHESIS OF AMINOCARBONYLCARBAMATES 1990
  • Ehdvard Dzhozef Glehmkovski[Us]
  • Julin Chiang[Us]
  • Rassel Richard Li Khejmer[Us]
RU2069664C1

RU 2 038 355 C1

Authors

Nikolas Dzh.Khrib[Us]

Dzhozef T.Strupzhevski[Us]

Dzhon G.Dzherkehk[Us]

Kennet Bordo[Us]

Dates

1995-06-27Published

1991-05-20Filed