ACETIC ACID DERIVATIVES OR HYDRATES THEREOF, OR SOLVATES THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF Russian patent published in 1997 - IPC

FIELD: medicine. SUBSTANCE: acetic acid derivatives of formula: HN (NH)C-X-Y-CO-Z-CH(Q′)COOQ′ wherein Q′ is hydrogen, phenylene; Q′ is hydrogen, phenyl lower alkyl; X is 1,4-phenylene, 2,5- pyridilene or 1,4-piperidinylene attached via hydrocarbon atom in position 4 to group Y. Y is group of formula: -(CH₂)_0-2-CONHCH(Q³)(CH₂)_1-31-CONHCH₂CH(Q⁴),, compound of formula 1 or compound of formula 2 or formulae 3 and 4; Q³ is hydrogen, methyl, phenyl, COOH or -CONH(CH₂)₂COOH; Q⁴ is hydrogen, methyl or phenyl; Z is 1,4- piperazinylene, 1,4-piperidinylene at attached via nitrogen atom in position 1 to group CO, or group of formula 5; Q′ is hydrogen, methyl, phenyl or COO lower alkyl; R″′ is residue attached via aminogroup of alpha- aminocarboxylic acid, or residue of ester of said acid or group of formula: -NHCH₂CH₂Ar or COR″′-carbamoyl or pyrrolidinoyl, Ar-phenyl unsubstituted or substituted with carboxy group of group -O(CH₂)_1-4COOH or hydrates thereof, or solvates thereof, or pharmaceutically acceptable salts thereof. Structure of compounds of formula 1,2,3,4 and 5. EFFECT: improved properties of the title compounds. 8 cl, 3 tbl