MEDICINAL AGENT AS OINTMENT FOR CUTANEOUS DISEASE AND CUTANEOUS MANIFESTATION OF IMMUNOLOGICALLY MEDIATED DISEASE TREATMENT AND/OR PROPHYLAXIS AND METHOD OF ITS SYNTHESIS Russian patent published in 1997 - IPC

FIELD: organic chemistry and technology. SUBSTANCE: product: tricycle compound of the formula (I) where: adjacent pairs R¹ and R², R³, and R⁴, R⁵ and R⁶ form other bond with carbon atoms or they mean H; R² can be lower alkyl; R⁷ - hydrogen, hydroxy-group, protected hydroxy-group, lower alkoxy-group; or R⁷ together with R¹ form oxo-group; R⁸ - hydrogen or hydroxy-group; R⁹ - lower alkyl, alkenyl or lower alkyl substituted with oxo-group; R¹⁰-R¹⁷ - independently hydrogen or lower alkyl; R¹⁸ and R¹⁹ - independently R18a

and hydrogen or R19a and hydrogen; R18a - hydroxy-group or lower alkoxy-group; R19a - hydroxy-group, lower alkoxy-group or protected hydroxy-group; n = 1 or 2; x¹ and x² - hydrogen or form together oxo-group; y¹ - hydrogen or hydroxy-group; y² - hydrogen or y¹ and y² form together oxo-group. Solubilizing agent and/or agent promoting impregnation: alkanediol, lower alkylene carbonate, alkanedicarboxylic acid ester, alkanecarboxylic acid glycerol ester, higher alkanecarboxylic acid alkyl ether, higher unsaturated alcohol and azacycloalkane. Ointment has tricycle compound or its pharmaceutically acceptable salt, solubilizing agent or agent promoting impregnation and ointment base taken at ratio, wt.-%: 0.01-10; 1-30 and the balance, up to 100%. Active component is dissolved in solubilizing agent or agent promoting impregnation, solution is mixed with an ointment base. EFFECT: improved method of synthesis, enhanced effectiveness of treatment and prophylaxis. 8 cl