FIELD: molecular biology, medicine. SUBSTANCE: invention relates to preparing the strain Escherichia coli C600r-m-/pAz219 toxA' - a producer of specific DNA-probe for differentiation of toxigenic and nontoxigenic strains of Corynebacterium diphtheriae. Strain provides high yield of plasmid DNA pAz 219 toxA' that is used for DNA/DNA hybridization as specific probe. Invention can be used for diagnosis of infectious diseases by method of nucleic acid hybridization. EFFECT: isolation of strain indicated above.
Authors
Dates
1997-07-27—Published
1993-09-23—Filed