STRAIN OF BACTERIUM ESCHERICHIA COLI - A PRODUCER OF SPECIFIC DNA-PROBE USED FOR DIFFERENTIATION OF TOXIGENIC AND NONTOXIGENIC STRAINS OF CORYNEBACTERIUM DIPHTHERIAE AND COMPLEMENTARY GENE TOX A DETERMINING SYNTHESIS OF DIPHTHERIN Russian patent published in 1997 - IPC

Abstract RU 2085581 C1

FIELD: molecular biology, medicine. SUBSTANCE: invention relates to preparing the strain Escherichia coli C600r-m-/pAz219 toxA' - a producer of specific DNA-probe for differentiation of toxigenic and nontoxigenic strains of Corynebacterium diphtheriae. Strain provides high yield of plasmid DNA pAz 219 toxA' that is used for DNA/DNA hybridization as specific probe. Invention can be used for diagnosis of infectious diseases by method of nucleic acid hybridization. EFFECT: isolation of strain indicated above.

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RU 2 085 581 C1

Authors

Mazurova I.K.

Zaikin V.L.

Jankovskij N.K.

Zdanovskij A.G.

Dates

1997-07-27Published

1993-09-23Filed